肝肾综合征门体循环失衡的机制与治疗

Mechanism and treatment of portal-systemic circulatory imbalance in hepatorenal syndrome

肝肾综合征是终末期肝病的严重并发症,其发生与门静脉高压、动脉血管扩张、心输出量和有效循环血量减少、肾动脉收缩等全身血流动力学改变,以及门体循环失衡相关。对于肝肾综合征的治疗,目前主要采用血管活性药物、介入等手段改变全身血流动力学、门体循环失衡,及早干预可改善患者预后。

Hepatorenal syndrome(HRS)is a serious complication of end-stage liver disease,and its pathogenesis is associated with the systemic hemodynamic changes such as portal hypertension,arterial vasodilation,reduced cardiac output,reduced effective circulating blood volume,and renal artery contraction,as well as portal-systemic circulatory imbalance.For the treatment of HRS at present,vasoactive agents and interventional treatment are used to change systemic hemodynamics and portal-systemic circulatory imbalance,and early intervention can improve the prognosis of patients.