麦门冬汤加减治疗肺间质纤维化患者的疗效观察

Analysis of the Curative Effect of Maimendong Decoction on Lung Function of Patients with Pulmonary Fibrosis

目的观察应用麦门冬汤加减对肺间质纤维化患者肺功能的临床疗效。方法选取2018年1月—2020年10月期间于菏泽市中医医院肺病科接受治疗的120例肺间质纤维化患者为研究对象,按随机数字表法将其分为研究组和对照组,每组各60例。对照组给予乙酰半胱氨酸胶囊治疗,研究组在对照组治疗基础上给予麦门冬汤加减治疗。治疗3个月后,观察比较两组患者临床疗效及治疗前后中医证候积分、肺功能、氧化应激水平[谷胱甘肽过氧化酶(Glutathione peroxidase,GSH-PX)、脂质过氧化物(lipid peroxidation,LPO)、过氧化氢酶(Catalase,CAT)]及血清炎症因子[C反应蛋白(C-reactive protein,CRP)、白介素-6(Interleukin-6,IL-6)、白介素-13(Interleukin-13,IL-13)、白介素-18(Interleukin-18,IL-18)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)]。结果治疗3个月后,研究组总有效率96.67%(58/60)明显高于对照组80.00%(48/60),两组比较,差异有统计学意义(P<0.05)。两组患者治疗3个月后咳吐浊唾涎沫、其质较黏稠,或咳痰带血、咳声不扬、甚则音嗄、气急喘促、皮毛干枯、形体消瘦、午后潮热、口渴咽燥、FEV1、VC、DLCO、TLC、GSH-PX、CAT、LPO均较治疗前改善,差异有统计学意义(P<0.05);且研究组咳吐浊唾涎沫、其质较黏稠,或咳痰带血、咳声不扬、甚则音嗄、气急喘促、皮毛干枯、形体消瘦、午后潮热、口渴咽燥、FEV1、VC、DLCO、TLC、GSH-PX、CAT、LPO均较对照组改善明显,差异有统计学意义(P<0.05)。结论麦门冬汤加减能够有效改善肺间质纤维化患者临床症状,提高肺功能,疗效显著,值得临床推广使用。

Objective To observe the effect of Maimendong Decoction on the lung function of patients with pulmonary fibrosis.Methods A total of 120 patients with pulmonary interstitial fibrosis who were treated in the Department of Pulmonary Diseases of Heze Traditional Chinese Medicine Hospital from January 2018 to October 2020 were selected as study subjects.They were divided into a study group and a control group according to a random number table.60 cases in each group.The control group was treated with acetylcysteine capsules,and the study group was treated with Maimendong Decoction on the basis of the control group.The clinical efficacy and TCM syndrome scores,lung function,and oxidative stress levels before and after treatment between the two groups of patients[Glutathione peroxidase(GSH-PX),lipid peroxidation,LPO),Catalase(Catalase,CAT)]and serum inflammatory factors[C-reactive protein(CRP),Interleukin-6(Interleukin-6,IL-6),Interleukin-13(Interleukin-13,IL-13),Interleukin-18(IL-18),Tumor necrosis factor-α(TNF-α)]were observe and compared of the two groups after treatment.Results After 3 months of treatment,the total effective rate of 96.67%(58/60)in the study group was significantly higher than 80.00%(48/60)in the control group.The difference between the two groups was statistically significant(P<0.05).After 3 months of treatment,the two groups of patients coughed,vomited,vomited,salivary foam,thicker,or coughed up bloody sputum,coughed poorly,even wheezing,shortness of breath,dry fur,weight loss,afternoon hot flashes,Thirst,dry mouth,FEV1,VC,DLCO,TLC,GSH-PX,CAT,LPO were all improved compared with before treatment,the difference was statistically significant(P<0.05);and the study group’s cough,vomiting,salivation,and qualitative comparison Viscous,bloody sputum,poor cough,even wheezing,shortness of breath,dry fur,weight loss,afternoon hot flashes,dryness of thirst and throat,FEV1,VC,DLCO,TLC,GSH-PX,CAT Both LPO and LPO improved more significantly than the control group,and the difference was statistically significant(P<0.05).Conclusion Maimendong Decoction can effectively improve the clinical symptoms of patients with pulmonary interstitial fibrosis,provide pulmonary effects,and has significant effects,which is worthy of clinical application.