围产期心肌病基因组学相关研究进展

Genomics Advances in Peripartum Cardiomyopathy

围产期心肌病是指妊娠晚期或产后5个月期间出现的一种特殊类型心肌病,以左室收缩功能障碍为主要表现。近十年来,围绕围产期心肌病相关基因组学开展了大量研究,这些研究结果为进一步了解围产期心肌病的发病机制提供了更多的理论基础。现围绕围产期心肌病相关基因,进行系统性综述。

Peripartum cardiomyopathy(PPCM)is a special type of cardiomyopathy that occurs late in pregnancy or within 5 months following delivery,which presents as heart failure syndromes and left ventricular ejection dysfunction.Recent ten years,there has been a number of studies focus on cardiomyopathy genetics in PPCM patients.Those studies provided theoretical basis of genetics on the mechanism of PPCM.This review summarizes genetics findings of PPCM.