磷酸镁骨水泥在骨折粘接固定中的应用效果分析

Research on Application Effect of Magnesium Phosphate Cement in Adhesive Fixation of Fracture

探究磷酸镁骨水泥在骨折粘接固定中的应用效果。首先分析骨折粘接固定中使用磷酸镁骨水泥的粘接强度,选择猪肋骨作为研究对象,将36只新鲜猪胫骨平均分为6个组,并将其平均分放到两种温度下进行固化,每种温度下的固化时间不同。然后分析骨折粘接固定中使用磷酸镁骨水泥的骨折愈合情况,选择30只健康兔作为实验对象,平均将其分为3个组,将磷酸镁骨水泥应用到骨折兔中,分析不同时期血磷、血镁和血钙离子浓度,并进行X线照片和CT检查,查看不同时期兔子的骨折愈合情况。结果表明,当固化温度为23℃时,固化时间为0.5 h和2 h的抗拉强度值分别为固化时间24 h的83.21%和97.88%;当固化温度为37℃时,固化时间为0.5 h和2 h的抗拉强度值分别为固化时间24 h的75.83%和93.30%;两种固化温度下的不同固化时间的样本抗拉强度进行两两比较,发现抗拉强度差异均无统计学意义(P>0.05);术前和术后兔子体内血磷、血镁和血钙离子浓度差异均无统计学意义(P>0.05);一个月后骨折部位对位线良好,磷酸镁骨水泥在使用之后能够降解吸收,达到较好的骨折愈合效果。所以骨折粘接固定中使用磷酸镁骨水泥具有一定的粘接固定作用,对离子浓度几乎没有影响,可以在动物体内降解吸收,能够实现骨折断面的直接粘接固定,属于一种较为理想的骨水泥。

To explore the application effect of magnesium phosphate cement in fracture bonding and fixation, the first is to analyze the bonding strength of magnesium phosphate cement. Pig ribs are selected as the research object, and there are 36 fresh pig tibias divided into 6 groups on average. At the same time, they are evenly placed at two temperatures for curing, and the curing time is different at each temperature. Then the fracture healing of using magnesium phosphate cement has been observed. There are 30 healthy rabbits selected as experimental subjects, which are divided into 3 groups on average. Then apply magnesium phosphate cement to the fractured rabbits, and analyze the ion concentration of blood phosphorus in different periods, blood magnesium and blood calcium. In addition, X-ray photographs and CT examinations has been performed to check the fracture healing of rabbits in different periods. The results show that when the curing temperature is 23℃, the tensile strength values for curing time of 0.5 h and 2 h account for 83.21% and 97.88% of the curing time of 24 h, respectively;when the curing temperature is 37℃, the tensile strength values account for 75.83% and 93.30%. The samples tensile strengths with different curing times at the two curing temperatures are compared in pairs, and there are no statistical significance for the differences in tensile strength(P > 0.05). And there are no statistically significance for ion concentration differences of blood phosphorus, blood magnesium, and blood calcium in rabbits before and after surgery(P > 0.05). After one month, the alignment of fracture site is good, and the magnesium phosphate cement is able to be degraded and absorbed, so as to achieve better fracture healing effect. Therefore, magnesium phosphate bone cement has a certain bonding and fixation effect for fracture, and it has almost no effect on ion concentration. Magnesium phosphate bone cement can be degraded and absorbed in animals, and it can be used to directly bond and fix the fracture section. Thus, magnesium phosphate bone cement is a relatively ideal bone cement.