中重度宫腔粘连术后应用不同剂量雌激素对预后的影响

Effect of Different Doses of Estrogen on the Prognosis of Moderate to Severe Intrauterine Adhesions

目的:分析和研究中重度宫腔粘连患者在术后应用不同剂量雌激素治疗对其临床预后的作用及影响。方法:随机抽选2017年1月至2020年1月开封市人民医院收治的中重度宫腔粘连患者58例,且均行宫腔镜粘连分解手术治疗,抽签法随机对患者进行术后治疗分组,对照组29例,观察组29例。对照组术后予以小剂量雌激素治疗,观察组术后予以大剂量雌激素治疗,回顾性分析两组患者的预后结果情况。结果:治疗后3个月,观察组患者的子宫内膜增殖中期厚度以及子宫内膜分泌晚期厚度均大于对照组,差异具有统计学意义(P<0.05);在月经改善率、宫腔形态恢复率以及临床总有效率方面,观察组患者(93.10%,86.21%,93.10%)均高于对照组(62.07%,55.17%,79.31%),差异具有统计学意义(P<0.05)。结论:中重度宫腔粘连患者手术后应用大剂量雌激素进行治疗,其预后效果良好,症状改善明显。

Objective To analyze and study the effect and influence of different doses of estrogen therapy on the clinical prognosis of patients with moderate to severe intrauterine adhesions.Methods 58 patients with moderate to severe intrauterine adhesions admitted to Kaifeng People’s Hospital from January 2017 to January 2020 were randomly selected,and all were treated with hysteroscopic adhesion decomposition surgery.The patients were randomly divided into groups for postoperative treatment by drawing lots.There were 29 cases in the control group and 29 cases in the observation group.The control group was treated with lowdose estrogen after operation,and the observation group was treated with high-dose estrogen after operation.The prognostic results of the two groups were retrospectively analyzed.Results 3 months after treatment,the thickness of the observation group in the middle stage of endometrial proliferation and the thickness of the late endometrial secretion were greater than those of the control group,the differences were statistically significant(P<0.05);The menstrual improvement rate and the uterine cavity shape recovery rate and total clinical effective rate,in the observation group(93.10%,86.21%,93.10%)were higher than those in the control group(62.07%,55.17%,79.31%),the differences were statistically significant(P<0.05).Conclusion Patients with moderate to severe intrauterine adhesions are treated with high-dose estrogen after surgery,the prognosis is good,and the symptoms are improved significantly.