脑心通联合盐酸纳洛酮治疗脑梗死的效果评估

Evaluation of the Effect of Naoxintong Capsule Combined with Naloxone Hydrochloride in the Treatment of Cerebral Infarction

目的:评估盐酸纳洛酮在脑梗死治疗中的应用价值。方法:选取2019年4月至2020年3月在南阳市第一人民医院进行治疗的86例脑梗死患者,将其随机分为观察组(43例)和对照组(43例)。所有患者入院后均接受基础治疗,予以对照组脑心通胶囊口服治疗,观察组患者在对照组治疗基础上同时接受盐酸纳洛酮治疗。比较两组患者神经功能缺损改善效果及用药安全性。结果:治疗前两组患者美国国立卫生研究院脑卒中量表(NIHSS)评分比较,差异无统计学意义(P>0.05);治疗后各时间段观察组患者NIHSS评分均低于对照组,差异具有统计学意义(P<0.05)。观察组患者临床总有效率明显高于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对脑梗死患者进行盐酸纳洛酮治疗可促进神经功能缺损改善,提高治疗效果,而且应用安全性较高。

Objective To evaluate the application value of naloxone hydrochloride in the treatment of cerebral infarction.Methods A total of 86 patients with cerebral infarction who were treated in Nanyang First People's Hospital from April 2019 to March 2020 were selected and randomly divided into observation group(43 cases)and control group(43 cases).All patients received basic treatment after admission,and patients in the control group were treated with Naoxintong capsules orally.Patients in the observation group received naloxone hydrochloride treatment in addition to the treatment in the control group.The improvement effect of neurological deficits and the safety of medication were compared between the two groups.Results Before treatment,there was no significant difference in the scores of the national institutes of health stroke scale(NIHSS)between the two groups of patients(P>0.05);After treatment,the NIHSS scores of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).The total clinical effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05).Conclusion Providing naloxone hydrochloride treatment for patients with cerebral infarction can promote the improvement of neurological deficits,improve the therapeutic effect,and have high application safety.