期刊文献+

自拟健脾消癌益肾方对晚期转移性结直肠癌化疗患者肿瘤标志物及基质金属蛋白酶2水平的影响 被引量:3

Effect of Self-made Jianpi Xiaoai Yishen Recipe on Tumor Markers and Matrix Metalloproteinase-2 Levels in Patients with Advanced Metastatic Colorectal Cancer Undergoing Chemotherapy
下载PDF
导出
摘要 目的:探究自拟健脾消癌益肾方对晚期转移性结直肠癌化疗患者肿瘤标志物及基质金属蛋白酶2(MMP-2)水平的影响。方法:选取该院2018年3月到2020年3月治疗的晚期结直肠癌患者87例为研究对象,随机数字表法分为2组,对照组43例进行常规XELOX化疗,观察组44例联合健脾消癌益肾方。对比2组近期疗效、免疫因子、肿瘤标志物及基质金属蛋白酶2(MMP-2)、环氧化酶-2水平(cox-2)水平。结果:观察组临床疗效高于对照组,(P<0.05);观察组CD4+、CD3+、CD4+/CD8+、环氧化酶-2(cox-2)高于对照组,癌胚抗原(CEA)、糖类抗原-724(CA724)、基质金属蛋白酶2(MMP-2)水平低于对照组,(P<0.05)。结论:常规化疗联合自拟健脾消癌益肾方可以有效改善患者免疫功能以及血清因子水平,抑制肿瘤标志物发展,提高临床治疗效果。 Objective:To explore the effect of self-made Jianpi Xiaoai Yishen Recipe on tumor markers and matrix metalloproteinase 2 (MMP-2) levels in patients with advanced metastatic colorectal cancer undergoing chemotherapy.Methods:A total of 87 patients with advanced colorectal cancer treated in the hospital from March 2018 to March 2020 were selected as the research objects.They were divided into 2 groups by random number table.43 cases in the control group received conventional XELOX chemotherapy,and 44 cases in the observation group combined Recipe for strengthening the spleen,eliminating cancer and replenishing the kidney.The short-term efficacy,immune factors,tumor markers,matrix metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (cox-2) levels were compared between the two groups.Results:The clinical efficacy of the observation group was higher than that of the control group (P<0.05);the observation group CD4+,CD3+,CD4+/CD8+,cyclooxygenase-2 (cox-2) were higher than the control group,carcinoembryonic antigen (CEA),The levels of carbohydrate antigen-724 (CA724) and matrix metalloproteinase 2 (MMP-2) were lower than those of the control group (P<0.05).Conclusion:Routine chemotherapy combined with self-made Jianpi Xiaoai Yishen Recipe can effectively improve the patient’s immune function and serum factor levels,inhibit the development of tumor markers,and improve the clinical treatment effect.
作者 马俊华 蔡超 张军峰 MA Junhua;CAI Chao;ZHANG Junfeng(Hebi City People’s Hospital of Henan Province,Henan Hebi 458030,China)
出处 《中医药临床杂志》 2021年第11期2180-2183,共4页 Clinical Journal of Traditional Chinese Medicine
关键词 自拟健脾消癌益肾方 晚期转移性结直肠癌 肿瘤标志物 基质金属蛋白酶2 Self-made prescription for Jianpi Xiaoai Yishen Advanced metastatic colorectal cancer Tumor markers Matrix metalloproteinase 2
  • 相关文献

参考文献19

二级参考文献256

共引文献5207

同被引文献45

引证文献3

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部