交泰丸治疗心肾不交型失眠的临床机制研究概况

Research of Jiaotai Pill Mechanism in Treating Insomnia of Heart-kidney Disharmony Type

阐述了交泰丸治疗心肾不交型失眠的临床机制研究概况。交泰丸可以用于治疗心火亢盛、肾阳亏虚之心肾不交型失眠,其治疗失眠的西医机制多与调控促觉醒与促睡眠类神经递质、抑制HPA轴、调节细胞因子与信号通路、减少自主活动、抑制DNA甲基化水平、影响生物钟蛋白和调节基因等因素有关。

Describes the research overview of the clinical mechanism of Jiaotai Pills in the treatment of heart-kidney disjoint insomnia.Jiaotai Pills can be used to treat insomnia caused by hyperactive heart fire and deficiency of kidney yang.The western medicine mechanism of treating insomnia is mostly related to regulating wake-up and sleep-promoting neurotransmitters,inhibiting HPA axis,and regulating cytokines.It is related to factors such as signaling pathways,reducing autonomous activities,inhibiting DNA methylation levels,affecting circadian clock proteins and regulating genes.