IOTA简单规则联合CDFI及血清CA125鉴别诊断卵巢肿瘤良恶性的价值

Value of IOTA simple rules combined with CDFI and serum CA125 in the differential diagnosis of benign and malignant ovarian tumor

目的探讨国际卵巢肿瘤分析组织(IOTA)简单规则联合CDFI及血清CA125鉴别诊断卵巢肿瘤良恶性的价值。方法选取经我院超声检查确诊为卵巢肿瘤的患者89例,根据术后病理结果分为良性组48例和恶性组41例,记录两组超声特征及血清肿瘤标志物CA125检查情况,并进行对比分析。绘制受试者工作特征(ROC)曲线分析IOTA简单规则、CDFI、血清CA125单独及联合应用诊断卵巢肿瘤良恶性的效能。结果良恶性组肿瘤形态、边界、内部回声、有无乳头状突起及血流分级比较差异均有统计学意义(均P<0.05);血清CA125比较差异有统计学意义(P<0.001)。ROC曲线分析显示IOTA简单规则、CDFI、血清CA125三者联合应用诊断卵巢肿瘤良恶性的敏感性、特异性、准确率分别为82.93%、95.83%、89.89%,与各方法单独应用比较差异均有统计学意义(均P<0.05)。结论 IOTA简单规则联合CDFI及血清CA125鉴别诊断卵巢肿瘤良恶性有较好的临床应用价值。

Objective To explore the value of the International Ovarian Tumor Analysis(IOTA) simple rules combined with CDFI and serum CA125 in the differential diagnosis of benign and malignant ovarian tumors.Methods A total of89 patients with ovarian tumors confirmed by ultrasound in our hospital were selected,and divided into 48 cases in benign group and 41 cases in malignant group according to postoperative pathological results.The ultrasonic characteristics of the two groups and the examination of serum CA125 were recorded.Receiver operating characteristic(ROC)curve was drawn to analyze the efficacy of IOTA simple rules,CDFI,and serum CA125 application alone and in combination in diagnosing benign and malignant ovarian tumors.Results There were statistically significant differences in tumor morphology,boundary,internal echo,papillary protrusion,and blood flow classification in the benign and malignant groups(all P<0.05).The difference in serum CA125 was statistically significant(P<0.001).ROC curve analysis showed that the sensitivity,specificity,and accuracy of the combined application of IOTA simple rules,CDFI,and serum CA125 in the diagnosis of benign and malignant ovarian tumors were 82.93%,95.83%,89.89%,respectively.Compared with the application alone,the difference were statistically significant(all P<0.05).Conclusion IOTA simple rules combined with CDFI and serum CA125 level have good clinical application value in the differential diagnosis of benign and malignant ovarian tumor.