新生儿高胆红素血症应用双歧杆菌对神经行为与情绪行为的改善价值

Value of Bifidobacterium in improving neurobehavior and emotional behavior in neonatal hyperbilirubinemia

【目的】探究新生儿高胆红素血症应用双歧杆菌对神经行为与情绪行为的改善价值。【方法】选取我院收治的106例患有新生儿高胆红血症的患儿,采用信封法将其分为两组。对照组采取蓝光治疗,观察组在对照组基础上加用双歧杆菌。观察两组血清胆红素、疗效及神经行为等指标。【结果】观察组胆红素水平在治疗3 d、治疗4 d、治疗5 d均低于对照组(P<0.05);观察组总有效率高于对照组(P<0.05);观察组治疗后新生儿神经行为评估法(NBNA)总评分、行为能力、肌张力、原始反射、一般状态均高于对照组(P<0.05);治疗后观察组的眨眼频率低于对照组(P<0.05);观察组吮吸阻断后的安抚情况均较对照组好,两组不良反应情况无差异(P>0.05)。【结论】通过采用双歧杆菌联合方案,能有效降低高胆红素血症患儿体内胆红素水平,在提高疗效的同时,还能进一步改善患儿的神经行为及安抚情况,能够获得较好的临床价值,且安全性较好。

【Objective】To explore the value of Bifidobacterium in the improvement of neurobehavior and emotional behavior in neonatal hyperbilirubinemia.【Methods】A total of 106 children with neonatal hyperbilirubinemia treated in our hospital were divided into two groups by envelope method.The control group was treated with blue light,and the observation group was treated with Bifidobacterium on the basis of the control group.The indexes of serum bilirubin,curative effect and neurobehavior were observed.【Results】The level of bilirubin in the observation group was significantly lower than that in the control group at 3 days,4 days and 5 days of treatment(P<0.05);The total effective rate in the observation group was significantly higher than that in the control group(P<0.05);After treatment,the total score of neonatal neurobehavioral assessment(NBNA)in the observation group was significantly higher than that in the control group,and the behavioral ability,muscle tension,primitive reflex and general state in the observation group were significantly higher than those in the control group(P<0.05);After treatment,the blinking frequency of the observation group was significantly lower than that of the control group(P<0.05);The appeasement of the observation group was better than that of the control group,and there was no significant difference in adverse reactions between the two groups(P>0.05).【Conclusion】Through the use of Bifidobacterium combined scheme,it can effectively reduce the level of bilirubin in children with hyperbilirubinemia.While improving the curative effect,it can further improve the neurobehavior and comfort of children,obtain better clinical value and good safety.