原发性高血压老年患者血清富含半胱氨酸酸性分泌蛋白、DFR、半乳糖凝集素-3与颈动脉粥样硬化的相关性分析

Relationship between SPARC, DFR and Gal-3 and carotid atherosclerosis in elderly patients with essential hypertension

目的研究原发性高血压老年患者血清富含半胱氨酸酸性分泌蛋白(SPARC)、D-二聚体与纤维蛋白原之比(DFR)、半乳糖凝集素-3(Gal-3)与颈动脉粥样硬化的关系。方法将2019年8月—2020年8月于河北医科大学第二医院收治的原发性高血压患者132例设为观察组,将同期健康体检合格者90例设为对照组,检测并比较2组血清SPARC、DFR和Gal-3水平,比较高血压分级及颈动脉粥样硬化分级不同患者的血清SPARC、DFR和Gal-3水平,领动脉内膜中层厚度(CIMT)及斑块面积,分析血清SPARC、DFR与Gal-3水平与高血压分级及颈动脉粥样硬化分级的相关性。结果观察组SPARC、D-二聚体、纤维蛋白原、DFR和Gal-3检测值均显著高于对照组(P<0.05);IMT、斑块面积及血清SPARC、DFR和Gal-3水平均随着高血压分级的增高而上升(P<0.05);颈动脉粥样硬化分级中,2~3级患者血清SPARC、DFR和Gal-3水平均显著高于0~1级患者(P<0.05);相关性分析提示,血清SPARC、DFR、Gal-3水平与高血压分级及颈动脉粥样硬化分级均呈正相关(P<0.05)。结论SPARC、DFR和Gal-3在原发性高血压老年患者血清中呈高表达水平,并与颈动脉粥样硬化关系密切。

Objective To study the relationship between serum cysteine rich acidic secretory protein(SPARC),Ddimer to fibrinogen ratio(DFR)and galactose lectin-3(Gal-3)and carotid atherosclerosis in elderly patients with essential hypertension.Methods 132 patients with essential hypertension treated in Second Hospital of Hebei Medical University from August2019 to August 2020 were set as the observation group,and 90 healthy people who passed the physical examination were set as the control group.The levels of serum SPARC,DFR and Gal-3 of the two group were detected and compared.The levels of serum SPARC,DFR and Gal-3 of patients with different hypertension grades and carotid atherosclerosis grades were compared.The relationship between hypertension grades and IMT was analyzed.The correlations between the levels of serum SPARC,DFR and Gal-3 and the grade of hypertension and carotid atherosclerosis were analyzed.Results The levels of serum SPARC,D-D,FIB,DFR and Gal-3 of the observation group were significantly higher than those of the control group(P<0.05).The IMT,plaque area and the levels of serum SPARC,DFR and Gal-3 increased with the increase of hypertension grade(P<0.05).The levels of serum SPARC,DFR and Gal-3 of patients with carotid atherosclerosis grade 2~3 were significantly higher than those of patients with carotid atherosclerosis grade 0~1(P<0.05).Correlation analysis showed that the levels of serum SPARC,DFR and Gal-3 were positively correlated with the grade of hypertension and carotid atherosclerosis(P<0.05).Conclusion SPARC,DFR and Gal-3 are highly expressed in serum of elderly patients with essential hypertension,which is closely related to carotid atherosclerosis.