斑蝥素乳膏外用治疗儿童传染性软疣的临床疗效观察

Clinical observation of cantharidin for the treatment of molluscum contagiosum in children

目的:探讨0.025%斑蝥素乳膏外用治疗儿童传染性软疣的临床疗效,并评估其安全性。方法:采用随机对照研究,观察2019年8月——2020年9月就诊于南京市儿童医院皮肤科的110例传染性软疣患儿,分别外用0.025%斑蝥素乳膏和刮疣术治疗,评价其临床疗效、安全性及家长满意度。结果:0.025%斑蝥素乳膏治疗儿童传染性软疣总有效率77.1%,水疱的发生率74.2%,疼痛28.6%,瘙痒24.3%,未观察严重不良反应,未发现皮肤感染或瘢痕。家长总满意度55.2%。结论:低浓度的斑蝥素乳膏安全有效,治疗中建议封包1~2 h,可作为儿童传染性软疣治疗方法之一。

Objective: To determine the safety and efficacy of 0.025% cantharidin therapy for molluscum contagiosum(MC) in children. Methods: A randomized controlled study was conducted to evaluate the clinical efficacy and safety of topical 0.025%cantharidin and clearing therapy in 110 children with MC, and the parents’ satisfaction was also assessed. Results: The total efficacy of cantharidin therapy was 77.1%. Blisters at the site of application occurred to 74.2% of patients. Pain was reported in 28.6% of the patients, and pruritus in 24.3%. No major side effects, secondary bacterial infection or scars were reported.The parents’ satisfaction rate was 55.2%. Conclusion: Cantharidin of low concentration is safe and effective. Cantharidin pack for 1-2 hours is recommended as a treatment method for molluscum contagiosum in children.