摘要
生物膜是细菌生长的动态过程,其产生的胞外成分可增强细菌对宿主防御机制和抗生素的抵抗力。耐药细菌生物膜的形成将是临床感染治疗与控制的一大挑战。肺炎克雷伯菌是临床常见的致病菌,高毒力型肺炎克雷伯菌与耐碳青霉烯肺炎克雷伯菌可引起严重的感染性疾病,难以治愈,其生物膜的形成使这种情况更加严峻。对肺炎克雷伯菌生物膜形成及其调控机制的深入研究可为临床抗感染治疗与控制带来新的思路。本文主要从菌毛、多糖、群体感应系统和外排泵对肺炎克雷伯菌生物膜形成的作用及调控机制的最新研究进展进行综述。
The biofilm formation is a dynamic process of bacterial growth,and the extracellular components can encase these microorganisms,making them more resistant to antibiotics and host immune attack.The formation of antibiotic-resistant bacterial biofilms will be a major challenge for the treatment and control of clinical infections.Klebsiella pneumoniae is a common clinical pathogen.Hypervirulent K.pneumoniae and carbapenem-resistant K.pneumoniae can cause serious infectious diseases,and the formation of its biofilm will aggravate this situation.In-depth research on the formation of K.pneumoniae biofilm and its regulatory mechanism can shed light on clinical anti-infection treatment and control.This article mainly reviews the latest research progress in the effects of fimbriae,polysaccharides,quorum sensing systems,and efflux pumps on the formation of K.pneumoniae biofilm and their regulatory mechanisms.
作者
贾雯
郭瑞林
JIA Wen;GUO Ruilin(Department of Medical Technology,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712000,China;Clinical Laboratory,the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712000,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2021年第6期936-944,共9页
Acta Academiae Medicinae Sinicae
关键词
肺炎克雷伯菌
生物膜形成
调控机制
Klebsiella pneumoniae
biofilm formation
regulatory mechanism