期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

褪黑素对冈田酸毒性拟阿尔茨海默病大鼠脑突触超微结构的改善作用 被引量：2

The effect of melatonin on the ultrastructure of brain synapses in Okadaic acid-induced Alzheimer’s disease rats
下载PDF
导出
摘要 在冈田酸(okadaic acid,OA)毒性拟阿尔茨海默病(Alzheimer’s disease,AD)大鼠模型上,探讨褪黑素(melatonin,MT)对AD动物模型学习记忆能力、海马和皮质神经元及突触超微结构的改善作用,初步阐明MT抗AD作用与对脑突触超微结构的保护作用的关系。 In the Alzheimer’s disease rat model of okadaic acid,to explore the effects of melatonin(MT)on the improvement of synaptic ultrastructure of AD animals which to clarify the relationship between the anti-AD effect of MT and the protective effect on brain synaptic ultrastructure.
作者 吴敏霞 许盈 周琳瑛 林曦 胡祥炬 WU Min-xia;XU Ying;ZHOU Lin-ying;LIN Xi;HU Xiang-ju(Electron Microscopy Lab of Public Technology Service Center,Fujian Medical University,Fuzhou Fujian 350122;Department of Pharmacology,School of Pharmacy,Fujian Medical University,Fuzhou Fujian 350122;School of Public Health,Fujian Medical University,Department of Endemic and Chronic Noncommunicable Diseases,Fujian Provincial Center for Disease Control and Prevention,Fuzhou Fujian 350001,China)
机构地区 福建医科大学公共技术中心电镜室 福建医科大学药学院药理学系 福建医科大学公共卫生学院
出处 《电子显微学报》 CAS CSCD 北大核心 2021年第6期726-730,共5页 Journal of Chinese Electron Microscopy Society
基金 福建省自然科学基金资助项目(No.2018J01832) 福建省自然科学基金资助项目(No.2019J01307) 福建省卫生健康中青年骨干人才培养项目(No.2020GGA023) 福建省科技创新联合资金项目(No.2018Y9074)。
关键词 褪黑素 冈田酸 阿尔茨海默病 超微结构 melatonin Okadaic acid Alzheimer’s disease ultrastructure
分类号 R741.02 [医药卫生—神经病学与精神病学] R361 [医药卫生—病理学]
  • 相关文献

参考文献2

二级参考文献14

  • 1Sonkusare S K, Kaul C L, Ramarao P. Dementia of Alzheimer's disease and other neurodegenerative disordersmemantine, a new hope [ J ]. Pharmacol Res, 2005,5 : 1 - 17.
  • 2Markesbery W R. Oxidative stress hypothesis in Alzheimer's disease[J]. Free Radicals Biol Med, 1997,23( 1 ):134-147.
  • 3Sharma M, Gupta Y K. Intracerebroventricular injection of streptozotocin in rats produces both oxidative stress in the brain and cognitive impairment [J]. Life Scien, 2001,68 (9) :1021 - 1029.
  • 4Rivera E,Goldin A,Fulmer N,Tavares R,Wands J R,De la Monte S M. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer' s disease: Link to brain reductions in acetylcholine [ J]. J Alzheimers Dis ,2005,8:247 - 268.
  • 5De la Monte S M, Wands J R. Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease[J]. J Alzheimers Dis,2005,7(1) :45 - 61.
  • 6Steen E,Terry B M,Rivera E J,et al. Impaired insulin and insulin-hke growth factor expression and signaling mechanisms in Alzheimer' s disease-is this type 3 diabetes [J]. J Alzheimers Dis,2005,7(1):63- 80.
  • 7Plaschke K, Hoyer S. Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus [ J]. Int J Dev Neurosci, 1993,11 (4) :477 - 483.
  • 8Duelli R, Schrock H, Kuschinsky W, Hoyer S. Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rat [J]. Int J Dev Neurosci,1994,12(8) :737 - 743.
  • 9Hoyer S, Lee S K, Loffler T, Schliebs R. Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease[J]. Ann N Y Acad Sci,2000,920:256 - 258.
  • 10Lannert H, Hoyer S. Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats[J]. Behav Neurosci, 1998, 112 (5): 1199 - 1208.

共引文献34

同被引文献23

引证文献2

二级引证文献1

电子显微学报
2021年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部