皮肤鳞状细胞癌血清PD-L1、Annexin A2表达及其临床意义

Expressions and clinical significance of serum PD-L1 and Annexin A2 in cutaneous squamous cell carcinoma

目的:探讨皮肤鳞状细胞癌(CSCC)血清程序性死亡配体-1(PD-L1)、膜联蛋白A2(Annexin A2)表达及其临床意义。方法:选取81例CSCC患者为研究组,40例同期皮肤良性病变患者为对照组。比较两组患者及研究组不同病理特征和预后患者血清PD-L1、Annexin A2表达水平;分析PD-L1、Annexin A2在CSCC与皮肤良性病变鉴别诊断中的价值及其表达水平与临床病理特征和预后的相关性。结果:研究组患者血清PD-L1、Annexin A2高于对照组(P<0.05)。研究组不同性别、年龄、肿瘤部位患者血清PD-L1、Annexin A2水平比较,差异无统计学意义(P>0.05);不同淋巴结转移情况、分化程度、肿瘤大小、预后情况患者血清PD-L1、Annexin A2水平比较,差异有统计学意义(P<0.05)。ROC曲线分析显示,血清PD-L1和Annexin A2诊断CSCC的敏感性分别为85.00%和92.50%,特异性分别为87.65%和58.02%。相关分析显示,CSCC患者血清PD-L1、Annexin A2与淋巴结转移情况、分化程度、肿瘤大小、预后情况水平呈正相关(PD-L1:r=0.711、0.552、0.338、0.261,P<0.05;Annexin A2:r=0.299、0.299、0.334、0.230,P<0.05)。结论:血清PD-L1、Annexin A2与CSCC患者部分临床病理特征及预后存在一定联系,有一定诊断价值。

Objective:To explore the expressions and clinical significance of serum programmed death ligand-1(PD-L1)and Annexin A2 in cutaneous squamous cell carcinoma(CSCC).Methods:81 patients with CSCC(study group)and 40 patients with benign skin lesions(control group)were retrospectively analyzed.The expression levels of serum PD-L1 and annexin A2 in patients with different pathological features and prognosis were compared between the two groups.The diagnostic value and expression levels of PD-L1 and Annexin A2 on distinguishing CSCC and benign skin lesions was analyzed,and the correlation between clinicopathological characteristics and prognosis in patients were analyzed.Results:The levels of serum PD-L1 and Annexin A2 in study group were higher than those in control group(P<0.05).There were no statistical differences in the levels of serum PD-L1 and Annexin A2 among patients with different genders,ages and tumor sites in the study group(P>0.05),and there were significant differences in the levels of serum PD-L1 and Annexin A2 among patients with different lymph node metastases,differentiation degrees,tumor sizes and prognosis(P<0.05).ROC curve analysis of diagnostic efficacy of serum PD-L1 and Annexin A2 showed that the sensitivity and specificity were 85.00%and 87.65%of serum PD-L1 and 92.50%and 58.02%of Annexin A2 respectively.Spearman correlation analysis showed that serum PD-L1 and Annexin A2 in patients with CSCC were positively correlated with lymph node metastasis,differentiation degree,tumor size and prognosis(PD-L1:r=0.711,0.552,0.338,0.261,Annexin A2:r=0.299,0.299,0.334,0.230,all P<0.05).Conclusion:Serum PD-L1 and Annexin A2 have a certain relationship with some clinicopathological characteristics and prognosis of patients with CSCC,and they have certain diagnostic value.