慢性肾脏病患者的血脂管理及其对预后的影响

Lipid management of patients with CKD and its effect on the prognosis

慢性肾脏病(CKD)患者的血脂异常不仅患病率高,也较一般人群更为复杂,科学的血脂管理有助于减少CKD患者心血管事件等并发症的发生。调脂药物在CKD防治中的应用价值,尤其是对蛋白尿、肾小球滤过率等的影响方面,目前尚存争议。本文对CKD患者的脂代谢特点、血脂管理路径、调脂药物选择及其预后影响等近年来研究结果进行综述,旨在为CKD患者的血脂管理获益最大化提供参考。

The dyslipidemia of patients with chronic kidney disease(CKD)not only has a high prevalence rate,but is also more complicated than the general population.Scientific lipid management can help reduce the occurrence of complications such as cardiovascular events in CKD patients.There is still controversy about the application value of lipid-regulating drugs in the prevention and treatment of CKD,especially in their impact on the proteinuria and glomerular filtration rate,etc.This article reviewed recent research results including the characteristics of lipid metabolism,pathways of lipid management,choice of lipid-regulating drugs,and their effects on the prognosis,aiming to provide a reference for maximizing the benefits of lipid management in CKD patients.