基于SnO_(2)/TiO_(2)/Au NPs纳米复合材料发展光电化学方法特异性检测唾液酸

The development of photoelectrochemical method for specific detection of sialic acid based on SnO_(2)/TiO_(2)/Au NPs

制备了氧化铟锡(ITO)/二氧化锡(SnO_(2))/二氧化钛(TiO_(2))/金纳米粒子(Au NPs)纳米复合电极(ITO/SnO_(2)/TiO_(2)/Au NPs),并利用它发展了可以选择性检测唾液酸(SA)的光电化学(PEC)法.采用旋涂法制备了ITO/SnO_(2)电极,并通过静电纺丝和磁控溅射技术在ITO/SnO_(2)表面原位合成了TiO_(2)纳米纤维和Au NPs.与单纯SnO_(2)比,ITO/SnO_(2)/TiO_(2)/Au NPs纳米复合电极的光电性能显著提高.这可能与Au NPs的局域表面等离子体共振效应(LSPR)和TiO_(2)/SnO_(2)异质结之间的协同作用密切相关.之后,通过金硫键(Au-S)将四巯基苯硼酸(4-MPBA)修饰在ITO/SnO_(2)/TiO_(2)/Au NPs电极表面,利用4-MPBA和SA之间的非特异性酯化反应,发展了可以特异性检测SA的PEC传感平台.

In this work,indium tin oxide(ITO)/tin oxide(SnO_(2))/titanium dioxide(TiO_(2))/gold nanoparticles(Au NPs)nanocomposite electrode(ITO/SnO_(2)/TiO_(2)/Au NPs)was prepared and used to develop a photoelectrochemical(PEC)method for the selective detection of sialic acid(SA).Firstly,ITO/SnO_(2) electrode was prepared by spin coating method,and then TiO_(2) nanofibers and Au NPs were synthesized on the surface of ITO/SnO_(2) by electrospinning and magnetron sputtering.Compared with pure SnO_(2),the photoelectric performance of ITO/SnO_(2)/TiO_(2)/Au NPs nanocomposite electrode is significantly improved.This may be closely related to the local plasmon resonance effect(LSPR)of Au NPs,and the synergistic effect between TiO_(2)/SnO_(2) heterojunction.After that,4-mercaptophenylboronic acid(4-MPBA)was modified on the surface of ITO/SnO_(2)/TiO_(2)/Au NPs electrode by Au-S bond,and a PEC sensing platform was developed to specifically detect SA by non-specific esterification reaction between 4-MPBA and SA.