栀子大黄汤加减联合双歧杆菌三联活菌肠溶胶囊、蓝光照射治疗新生儿病理性黄疸的效果

Effect of Modified Zhizi Dahuang Decoction Combined with Bifidobacterium Triple Viable Enteric-coated Capsules and Blue Light Irradiation on Neonatal Pathological Jaundice

目的观察栀子大黄汤加减联合双歧杆菌三联活菌肠溶胶囊、蓝光照射治疗新生儿病理性黄疸的临床效果。方法选取2019年10月-2021年9月我院诊治的68例病理性黄疸新生儿为研究对象,采用随机数字表法分为对照组和观察组,各34例。对照组采用双歧杆菌三联活菌肠溶胶囊和蓝光照射治疗,观察组在对照组基础上给予栀子大黄汤加减治疗,比较两组临床治疗总有效率、黄疸消退时间和住院时间、血清胆红素水平和超敏-C反应蛋白、不良反应发生率。结果观察组治疗总有效率为91.18%,高于对照组的82.35%(P<0.05);观察组黄疸消退时间、住院时间短于对照组(P<0.05);观察组胆红素、超敏-C反应蛋白水平低于对照组(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论采用栀子大黄汤加减联合双歧杆菌三联活菌肠溶胶囊、蓝光照射治疗新生儿病理性黄疸的效果确切,可缩短黄疸消退和住院时间,降低血清胆红素和炎症细胞因子水平,且不会增加临床不良反应发生几率。

Objective To observe the clinical effect of modified Zhizi Dahuang decoction combined with bifidobacterium triple viable enteric-coated capsules and blue light irradiation in the treatment of neonatal pathologic jaundice.Methods A total of 68 neonates with pathological jaundice treated in our hospital from October 2019 to September 2021 were selected as the research objects.They were divided into control group and observation group by random number table method,with 34 cases in each group.The control group was treated with bifidobacteria triple viable enteric-coated capsules and blue light irradiation,and the observation group was treated with modified Zhizi Dahuang decoction on the basis of the control group.The total effective rate of clinical treatment,jaundice regression time and hospitalization time,serum bilirubin level,hypersensitivity-C reactive protein and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 91.18%,which was higher than 82.35%of the control group(P<0.05).The jaundice regression time and hospitalization time in the observation group were shorter than those in the control group(P<0.05).The levels of bilirubin and hypersensitivity-C reactive protein in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified Zhizi Dahuang decoction combined with bifidobacterium triple viable enteric-coated capsules and blue light irradiation is effective in the treatment of neonatal pathological jaundice,which can shorten the time of jaundice regression and hospitalization,reduce the levels of serum bilirubin and inflammatory cytokines,and will not increase the incidence of clinical adverse reactions.