石斛养胃汤联合胶体果胶铋干混悬剂及阿莫西林治疗慢性萎缩性胃炎的临床疗效观察

Clinical Efficacy of Shihu Yangwei Decoction Combined with Colloidal Bismuth Pectin for Suspension and Amoxicillin in the Treatment of Chronic Atrophic Gastritis

目的研究石斛养胃汤联合胶体果胶铋干混悬剂及阿莫西林对慢性萎缩性胃炎胃功能及血清炎性因子影响。方法选取2019年6月-2021年6月在我院治疗的84例慢性萎缩性胃炎患者为研究对象,采用随机数字表法分为对照组和观察组,各42例。对照组采用胶体果胶铋干混悬剂联合阿莫西林治疗,观察组在对照组基础上联合石斛养胃汤治疗,比较两组临床治疗总有效率、临床症状评分、胃功能指标、血清炎性因子水平以及临床不良反应发生情况。结果观察组治疗总有效率为92.86%,高于对照组的83.33%(P<0.05);治疗后,观察组临床腹痛、腹胀、嗳气、泛酸各症状评分小于对照组(P<0.05);两组胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)均高于治疗前,且观察组高于对照组(P<0.05);两组血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均低于治疗前,且观察组低于对照组(P<0.05);观察组不良反应发生率为4.76%,与对照组的7.14%比较,差异无统计学意义(P>0.05)。结论石斛养胃汤联合胶体果胶铋干混悬剂及阿莫西林治疗慢性萎缩性胃炎效果理想,可改善胃功能指标,提高治疗效果,降低血清炎性因子水平,减轻临床症状,且不良反应少,是一种有效、安全的联合治疗方案,值得临床加以应用。

Objective To study the effects of Shihu Yangwei decoction combined with colloidal bismuth pectin for suspension and amoxicillin on gastric function and serum inflammatory factors of chronic atrophic gastritis.Methods A total of 84 patients with chronic atrophic gastritis treated in our hospital from June 2019 to June 2021 were selected as the research objects.They were divided into control group and observation group by random number table method,with 42 cases in each group.The control group was treated with colloidal bismuth pectin for suspension and amoxicillin,and the observation group was treated with Shihu Yangwei decoction on the basis of the control group.The total effective rate,clinical symptom score,gastric function index,serum inflammatory factor level and clinical adverse reactions of the two groups were compared.Results The total effective rate of the observation group was 92.86%,which was higher than 83.33%of the control group(P<0.05).After treatment,the scores of clinical abdominal pain,abdominal distension,belching and pantothenic acid in the observation group were lower than those in the control group(P<0.05);gastrin-17(G-17)and pepsinogenⅠ(PGⅠ)in the two groups were higher than those before treatment,and those in the observation group were higher than the control group(P<0.05);the levels of serum C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 4.76%,which was compared with 7.14%in the control group,the difference was not statistically significant(P>0.05).Conclusion Shihu Yangwei decoction combined with colloidal bismuth pectin for suspension and amoxicillin in the treatment of chronic atrophic gastritis has an ideal effect,which can improve the gastric function index and the therapeutic effect,reduce the level of serum inflammatory factors,and relieve clinical symptoms.It is an effective and safe combined treatment scheme with few adverse reactions,which is worthy of clinical application.