摘要
肠缺血再灌注(ischemia-reperfusion,I/R)损伤是临床上常见的病理生理过程,是指组织或器官缺血后重获血供反而加重损伤的现象。其发病率逐年上升,但目前仍缺乏有效的治疗手段和药物。近年来间充质干细胞(mesenchymal stem cells,MSCs)移植治疗肠I/R损伤成为研究热点。本文对MSCs移植治疗肠I/R损伤的研究进展进行综述。
Ischemia-reperfusion(I/R)injury is a pathophysiological process in which the degree of tissue and organ damage is augmented after regaining blood supply on the basis of ischemic injury.Intestinal Ischemia/Reperfusion injury is common clinically;however,its treatment methods and relevant efficacy are limited.In recent years,mesenchymal stem cells(MSCs)transplantation has become a research hotspot in the treatment of intestinal I/R injury.This article reviews the research progress of MSCs therapy for intestinal I/R injury.
作者
徐蕴馨
王清秀
XU Yun-xin;WANG Qing-xiu(Shanghai East Hospital Clinical Medical College,Nanjing Medical University,Nanjing 211166,China;Dept.of Anesthesiology,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200120,China)
出处
《同济大学学报（医学版）》
2021年第6期853-859,共7页
Journal of Tongji University(Medical Science)
基金
上海市浦东临床高峰学科(PWYgf2018-05)
上海市浦东新区卫生系统重要薄弱学科建设资助(PWZbr2017-18)。
关键词
间充质干细胞
肠缺血再灌注损伤
外泌体
免疫调节
炎症
mesenchymal stem cells
intestinal ischemia-reperfusion
exosomes
immune regulation
inflammation
