盐酸氨溴索联合头孢唑肟治疗小儿支气管肺炎的临床分析

Clinical analysis on ambroxol hydrochloride and ceftizoxime in the treatment for children with bronchial pneumonia

目的分析盐酸氨溴索联合头孢唑肟治疗小儿支气管肺炎的临床效果。方法采用前瞻性随机试验方法,选择2019年10月-2020年9月在我院接受治疗的198例小儿支气管肺炎患儿作为研究对象,依据随机数字表法分为对照组和观察组,各99例。对照组采用头孢唑肟治疗,观察组采用头孢唑肟+盐酸氨溴索治疗,持续治疗7d。对比治疗前和治疗7d结束时炎症反应指标[白介素-6 (IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子α(TNFr-α)]以及治疗期间退热时间、及咳痰消失时间。结果治疗7d结束时,2组血清IL-6、CRP、TNFr-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组退热时间、咳痰消失时间均短于对照组,差异有统计学意义(P<0.05)。结论盐酸氨溴索联合头孢唑肟治疗小儿支气管肺炎可减轻患儿炎症反应,改善症状,缩短治疗时间。

Objective To analyze the clinical effect of ambroxol hydrochloride combined with ceftizoxime in the treatment of children with bronchial pneumonia.Methods A prospective randomized trial method was used to select 198 children with bronchopneumonia treated in our hospital from Oct. 2019 to Sep. 2020 as the research subjects,according to the random number table method,they were divided into a control group and an observation group,with 99 cases in each group.The control group was treated with ceftizoxime, the observation group was treated with ceftizoxime + ambroxol hydrochloride, both were treated continuously for 7 days.The indexes of inflammatory reaction [interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α (TNFr-α)]before treatment and at the end of 7 days of treatment, and the time of fever abatement and disappearance of expectoration during treatment were compared.Results At the end of 7 days of treatment,the levels of serum IL-6,CRP and TNFr-α in both groups were lower than those before treatment, and it was lower in the observation group than that in the control group, there was statistical significance in the difference(P<0.05);The time of fever abatement and disappearance of expectoration of the observation group were shorter than those of the control group, there was statistical significance in the difference(P <0.05).Conclusions Ambroxol hydrochloride combined with ceftizoxime in the treatment of children with bronchial pneumonia can reduce the inflammatory reaction,improve symptoms and shorten the treatment time.