甘草颗粒联合丙酸氟替卡松吸入气雾剂治疗咳嗽变异性哮喘患儿的效果

Effect of Licorice Granule Combined with Fluticasone Propionate Inhalation Aerosol in the Treatment of Children with Cough Variant Asthma

目的探讨甘草颗粒联合丙酸氟替卡松吸入气雾剂治疗咳嗽变异性哮喘(CVA)患儿的效果。方法选取叶县妇幼保健院2019年1月至2020年8月收治的106例CVA患儿为研究对象,按随机数表法分为观察组和对照组,各53例。在常规干预的基础上,对照组接受丙酸氟替卡松吸入气雾剂治疗,观察组接受丙酸氟替卡松吸入气雾剂联合甘草颗粒治疗。对比两组疗效、转典型哮喘发生率及治疗前后中医证候积分、儿童哮喘控制测试量表(C-ACT)评分、肺功能[第1秒钟用力呼气容积(FEV_(1))、一秒率(FEV_(1)/FVC)、呼气峰流量(PEF)]、炎症因子[白细胞介素-4(IL-4)、白细胞介素-5(IL-5)、白细胞介素-13(IL-13)、一氧化氮(FENO)]水平及随访9个月复发率。结果观察组治疗总有效率[96.23%(51/53)]高于对照组[84.91%(45/53)](P<0.05);观察组治疗结束后1、5、9个月时复发率[0(0/53)、7.55%(4/53)、11.33%(6/53)]均低于对照组[11.33%(6/53)、22.64%(12/53)、28.30%(15/53)](P<0.05);观察组转典型哮喘发生率[5.66%(3/53)]低于对照组[24.53%(13/53)](P<0.05);观察组治疗后FEV_(1)、FEV_(1)/FVC、PEF均高于对照组,中医证候积分、C-ACT、IL-4、IL-5、IL-13、FENO低于对照组(P<0.05)。结论甘草颗粒与丙酸氟替卡松吸入气雾剂联合治疗CVA患儿,能改善患儿临床症状,提高患儿肺功能,减轻炎症反应,同时降低转变典型哮喘及复发的风险,疗效较好。

Objective To investigate the effect of licorice granule combined with fluticasone propionate inhalation aerosol in the treatment of children with cough variant asthma(CVA).Methods A total of 106 children with CVA admitted to Yexian Maternal and Child Health Hospital from January 2019 to August 2020 were selected as the research objects,and they were divided into observation group and control group according to the random number table method,with 53 cases in each group.On the basis of routine intervention,the control group received fluticasone propionate inhalation aerosol,and the observation group received fluticasone propionate inhalation aerosol combined with licorice granules.The curative effects and the incidence of typical asthma of the two groups were compared,and the traditional Chinese medicine syndrome scores,C-ACT scores,lung function[forced expiratory volume in the first second(FEV_(1)),forced expiratory volume in one second/forced vital capacity(FEV_(1)/FVC),peak expiratory flow(PEF)],the levels of inflammatory factors[Interleukin-4(IL-4),Interleukin-5(IL-5),Interleukin-13(IL-13),Nitric oxide(FENO)]before and after treatment and recurrence rate of 9 months follow-up were compared.Results The total effective rate of treatment in the observation group[96.23%(51/53)]was higher than that of the control group[84.91%(45/53)](P<0.05).The recurrence rate of the observation group at 1,5 and 9 months after the end of treatment[0(0/53),7.55%(4/53),11.33%(6/53)]were lower than those of the control group[11.33%(6/53),22.64%(12/53),28.30%(15/53)](P<0.05).The incidence of typical asthma in the observation group[5.66%(3/53)]was lower than that in the control group[24.53%(13/53)](P<0.05).The FEV_(1),FEV_(1)/FVC and PEF in the observation group were higher than those in the control group after treatment,and traditional Chinese medicine syndrome score,C-ACT,IL-4,IL-5,IL-13,FENO were lower than those of the control group(P<0.05).Conclusion The combination of licorice granules and fluticasone propionate inhalation aerosol in the treatment of CVA can improve the clinical symptoms of patients,improve the lung function of children,reduce inflammation,and reduce the risk of transformation of typical asthma and recurrence,and the effect is significant.