CT直方图参数对直肠癌肝转移患者化疗效果的评估价值

Evaluation Value of CT Histogram Parameters on the Effect of Chemotherapy in Patients with Liver Metastasis of Rectal Cancer

目的分析CT直方图参数对直肠癌肝转移患者化疗效果的评估价值。方法选择2018年1月至2021年1月于商丘市中心医院接受化疗的114例直肠癌肝转移患者为研究对象,观察并记录患者化疗4个疗程时的化疗效果并分组,分为有效组与无效组,调查并记录患者基线资料及化疗结束时CT直方图参数(方差、第99百分位数、跨度、熵),分析CT直方图参数对直肠癌肝转移患者化疗效果的评估价值。结果化疗4个疗程,114例患者中化疗无效22例,占19.30%。无效组患者CT直方图参数跨度、熵值大于有效组患者,差异有统计学意义(P<0.05)。CT直方图参数跨度、熵单独及联合检测评估直肠癌肝转移患者化疗效果的曲线下面积(AUC)分别为0.859、0.844、0.869,均有一定评估价值。结论CT直方图参数对直肠癌肝转移患者化疗效果具有一定评估价值。

Objective To analyze the value of CT histogram parameters in evaluating the effect of chemotherapy in patients with liver metastasis of rectal cancer.Methods A total of 114 patients with liver metastasis of rectal cancer who underwent chemotherapy in Shangqiu Central Hospital from January 2018 to January 2021 were selected as the research subjects.Observe and record the chemotherapy effect of patients during four courses of chemotherapy and divid them into effective group and ineffective group.The baseline data and CT histogram parameters(variance,99th percentile,span,entropy)of patients at the end of chemotherapy were investigated and recorded.The value of CT histogram parameters in evaluating the effect of chemotherapy in patients with liver metastasis of rectal cancer was analyzed.Results After 4 courses of chemotherapy among all 114 patients,22 cases were ineffective,accounting for 19.30%.The parameter span and entropy value of CT histogram of patients in the ineffective group were larger than those in the effective group(P<0.05).The area under the curve(AUC)of single and combined detection of CT histogram parameter span and entropy in evaluating the effect of chemotherapy in patients with liver metastasis of rectal cancer were 0.859,0.844 and 0.869,respectively,which had certain evaluation value.Conclusion CT histogram parameters have certain value in evaluating the effect of chemotherapy in patients with liver metastasis of rectal cancer.