围生期暴露与儿童支气管哮喘相关性的研究进展

Research progress of perinatal exposure and bronchial asthma in children

支气管哮喘是一种以慢性气道炎症和气道高反应性为特征的异质性疾病,我国儿童支气管哮喘的患病率呈逐年上升趋势,总体控制水平仍不理想。越来越多的证据表明,在生命早期发生的负面事件,甚至在围生期,会显著增加生命后期哮喘和肺功能不良的风险。本文就围生期暴露与儿童支气管哮喘相关性的研究现状进行综述。

Bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation and airway hyperresponsiveness. The prevalence rate of bronchial asthma in Chinese children is increasing year by year, and the overall level of control is still not ideal in Chinese children. There is growing evidence that negative events occurring early in life, even in the perinatal period, significantly increase the risk of asthma and poor pulmonary function later in life. This article reviews the researches on the relationship between perinatal exposure and bronchial asthma in children.