蛋白A免疫吸附联合免疫抑制剂治疗抗磷脂综合征顽固性血小板减少一例

Treatment of intractable thrombocytopenia in antiphospholipid syndrome by protein A immunoadsorption combined with immunosuppressive therapy

血小板减少是系统性红斑狼疮(systemic lupus erythematosus,SLE)合并抗磷脂综合征(antiphospholipid syndrome,APS)最常见的血液系统表现,与疾病严重程度密切相关。目前尚无统一治疗方案,传统丙种球蛋白冲击或血小板刺激因子治疗增加血栓性并发症的发生,而血浆置换存在出血和过敏等风险。本文报道1例SLE合并APS顽固性血小板减少,经蛋白A免疫吸附(protein A immunoadsorption,PAIA)治疗后血小板稳定至今,治疗过程无不良反应。