质子重离子放射治疗效果的系统评价再评价

Treatment with charged-particle radiation therapy:an overview of systematic reviews

目的对质子重离子放射治疗效果的系统评价进行再评价。方法计算机检索CNKI、WanFang Data、PubMed、EMbase数据库,检索时限均从2007年1月至2020年11月。由2名研究者独立筛选文献、提取资料,并采用AMSTAR 2评估纳入研究质量后,采用定性描述分析进行系统评价再评价。结果共纳入6篇系统评价。纳入的系统评价中,中等质量1篇、极低质量5篇。质子重离子放疗的应用广泛,对全身多部位多类型的肿瘤的治疗效果优于传统放射治疗方法,且不良反应少见、轻微。其中,重离子放疗的有效性和安全性均优于质子放疗。结论现有证据显示,质子重离子放疗的有效性、安全性较好,但系统评价的方法学质量有待提高,未来仍需高质量、大样本的研究验证。

Objective To overview the systematic reviews of the effectiveness and safety of the charged-particle radiation therapy.Methods Databases including CNKI,WanFang Data,PubMed,and EMbase were electronically searched from January 2007 to November 2020.Two investigators independently screened literature,extracted data,and assessed the quality of the included studies by AMSTAR 2,and then reported results through a narrative synthesis of outcomes.Results A total of 6 systematic reviews were identified.One systematic review demonstrated moderate quality and the other 5 demonstrated critically low quality.The charged-particle radiation therapy had a wide range of applications.Its effectiveness was superior to traditional radiotherapy methods on various types of tumors in various regions of the body,with acceptable side effects.Specifically,the effectiveness and safety outcomes of carbon ion radiotherapy was superior to those of proton radiotherapy.Conclusions Current evidence shows that the chargedparticle radiation therapy has superior effectiveness and limited toxicity,though the studies are of relatively low quality.High quality and larger sample size researches are required in the future.