局部后巩膜交联对眼球形状影响的有限元分析

Finite element analysis of the effect of local posterior sclera collagen cross-linking on eyeball shape

我国是高度近视高发国家,高度近视对视功能损害严重,目前尚缺乏有效的治疗手段。离体及在体动物实验表明后巩膜交联术能够有效阻止眼轴延长,但后巩膜局部交联后对整体眼球变形的影响尚不清楚。本文通过有限元模拟分析了后巩膜交联后眼球形状和光线投射在视网膜上的位置的变化,并编写相似性算法对其进行验证。结果发现,后巩膜交联前后完整的眼球形状仍然非常相似,交联后眼球的屈光度变化不大,几乎不会对光线在视网膜上的投射位置造成影响。表明后巩膜交联不会对视光造成扭曲,即不会因为巩膜局部交联后弹性模量的改变引起新的视光学问题。

China is the country with high incidence of high myopia in the world.High myopia can cause severe vision impairment.So far,there is no effective treatment for high myopia in clinic.Scleral collagen cross-linking surgery has been proven to be effective in preventing animal eye axial elongation in vitro and in vivo.However,the influence of posterior scleral collagen cross-linking on the deformation of the whole eyeball is still unclear.In this study,finite element simulation were used to analyze the changes of eyeball shape and the position of light casting on the retina after posterior sclera cross-linking,and the mathematical algorithm was written to verify their similarity.The results showed that the shape of the whole eyeball was still very similar before and after cross-linking,and the diopter of the eyeball after cross-linking had little change,which had almost no effect on the position of light projection on the retina.Our results indicate that posterior sclera cross-linking wouldn’t lead to distortion to the optometry,that is,the increase of elastic modulus in local scleral tissue after cross-linking wouldn’t cause new problem of optometry and vision.