Cu_(2-x)Se@MIL-100(Fe)-DOX的合成及多模式抗肿瘤研究

Synthesis and Multi-mode Anti-tumor Research of Cu_(2-x)Se@MIL-100(Fe)-DOX

采用高温溶剂注入法合成了形貌均匀的Cu_(2-x)Se纳米粒子,经聚乙烯吡咯烷酮修饰转水后通过一步溶液法在粒子表面包覆金属有机骨架MIL-100(Fe),最后利用MIL-100(Fe)介孔壳较大的比表面积和多孔结构负载上抗肿瘤药物阿霉素(DOX).Cu_(2-x)Se纳米粒子作为一种性能优异的新型光热剂,可以被近红外二区1064 nm光源激发并发挥肿瘤治疗作用;同时,Cu_(2-x)Se纳米粒子产生的光热提高了MIL-100(Fe)的化学动力学治疗效果、促进了抗癌药物阿霉素的释放进程.实验结果表明:该研究构建的纳米材料平台可以实现光热治疗、热促进化学动力学治疗和化学治疗3种乏氧肿瘤治疗策略的协同作用,具有潜在的应用价值.

The Cu_(2-x)Se nanoparticles with uniform morphology were firstly synthesized by high-temperature solvent-injection method.After being modified with polyvinylpyrrolidone,the surface of the particles was coated with metal organic framework MIL-100(Fe)by one-step solution method.Finally,MIL-100(Fe)mesoporous shell with the large specific surface area and porous structure was loaded with sufficient anti-tumor drug doxorubicin(DOX).As a new type of photothermal agent with excellent performance,Cu_(2-x)Se nanoparticles can be excited by the 1064 nm light source in the second region of the near-infrared and take effect.At the same time,the heat generated by the nanoparticles also greatly improves the chemodynamic treatment effect of MIL-100(Fe)and promotes the release of the anticancer drug doxorubicin.The constructed nano-platform can realize the synergy of three hypoxic tumor treatment strategies:photothermal therapy,thermally promoted chemodynamic therapy and and chemotherapy,which has great potential applications in the field of anti-cancer.