单采血小板献血者糖化血红蛋白检测分析

Analysis of glycosylated hemoglobin in apheresis platelet donors

目的为进一步保障献血者安全,了解单采血小板献血者人群糖化血红蛋白的水平,为单采血小板献血者招募策略提供指导。方法选取2018年7月~2020年12月的单采血小板献血者作为研究对象,抽取静脉血对所有初次或者3个月内未检测过糖化血红蛋白的献血者行糖化血红蛋白检测,以糖化血蛋白>6.0%为异常。结果共对986人献血者检测,发现了32人糖化血红蛋白异常者,异常率为3.25%(32/986)。随着年龄增长和身高体重指数(BMI)增高,糖化血红蛋白异常比例呈现增高趋势,但51~60岁年龄组和BMI>28.0组并非最高,可能和样本来源有一定关系。在不同年龄段中,糖化血红蛋白含量异常比例最高的为40~50岁年龄组,异常率为5.43%(15/276),最低的为18~25岁年龄组,异常率为0.85%(1/118)。在不同BMI的献血者中,异常率最高的BMI在"24.0~27.9"范围,为4.04%(9/223),最低为BMI>28.0的献血人群,未发现异常。结论糖化血红蛋白异常和年龄段及BMI密切相关。提示我们在招募献血者时候要优先考虑年轻的且体重不超标的献血者,有助于提高效率,也能更大程度的保障献血者安全。

Objective To investigate the level of glycosylated hemoglobin(HbA1 c) in apheresis platelet donors, so as to further ensure the safety of apheresis platelet donors and provide guidance for the recruitment strategy. Methods Apheresis platelet donors from July 2018 to December 2020 were selected and venous blood was drawn. The glycosylated hemoglobin detection was conducted for donors who had never did this before or did this 3 months ago, and glycosylated hemoglobin >6.0% was regarded as abnormal. Results A total of 986 blood donors were detected, among which 32 donors with abnormal glycosylated hemoglobin were found, rated at 3.25%. With the increase of age and BMI(height and body mass index), the proportion of abnormal glycosylated hemoglobin increased, but the 51~60 age group and BMI > 28.0 group were not the highest, which may be related to the source of samples.The rate of abnormal glycosylated hemoglobin was highest in 40~50 years old group(5.43%,15/276) and BMI ranged of 24.0~27.9(4.04%,9/223), and lowest(0.85%, 1/118) in 18~25 years old group and BMI >28.0(none).Conclusion The abnormal glycosylated hemoglobin is closely related to age and BMI. Therefore, we should give priority to young and underweight donors when recruiting blood donors, which can improve efficiency and maximize the safety of blood donors.