单发性和多发性腹膜透析相关性腹膜炎的临床特征及预后对照研究

The Clinical Features and Prognosis of Single and Multiple Peritonitis Associated with Peritoneal Dialysis

目的观察单发性和多发性腹膜透析相关性腹膜炎患者在临床特征、预后等方面的差异性。方法选取我院2016年1月至2020年12月期间收治的47例腹膜透析相关性腹膜炎患者作为研究对象,根据腹膜炎的发生次数,分为观察组(单发)32例和对照组(多发)15例,比较两组患者的临床特征,对照两组患者的预后。结果观察组患者的血红蛋白(Hb)水平[(99.17±3.65)g/L>(90.24±4.18)g/L,t=7.465]、白蛋白(Alb)水平[(31.79±1.63)g/L>(27.44±1.35)g/L,t=8.978]高于对照组(P<0.05),观察组患者的肌酐(Scr)水平、尿素氮(BUN)水平与对照组对比无显著差异(P>0.05)。观察组中,病情完全缓解、转血液透析以及发生死亡的患者比例并无显著差异(P>0.05)。在47例腹膜透析患者中,6例接受自动腹膜透析,41例接受常规手动的腹膜透析。接受自动腹膜透析治疗的患者,单发性腹膜透析相关性腹膜炎发生率高于常规手动的腹膜透析,多发性腹膜透析相关性腹膜炎发生率低于常规手动的腹膜透析。结论腹膜透析治疗期间,腹膜炎是常见的并发症。实验室检查结果提示,单发性和多发性腹膜透析相关性腹膜炎患者在Hb、Alb等指标上存在差异性,二者的预后并无显著差异。自动腹膜透析的应用,可以在一定程度上减少腹膜炎的发生次数。

Objective Observe the differences in clinical features and prognosis of patients with single and multiple peritonitis associated with peritoneal dialysis.Method A total of 47 patients with peritoneal dialysis-related peritonitis admitted to our hospital from January 2016 to December 2020 were selected as the research objects.According to the number of occurrences of peritonitis,they were divided into an observation group(single case)of 32 cases and a control group(multiple cases)of 15 cases,compare the clinical characteristics of the two groups of patients and control the prognosis of the two groups of patients.Result The hemoglobin(Hb)level of the observation group[(99.17±3.65)g/L>(90.24±4.18)g/L,t=7.465],the albumin(Alb)level[(31.79±1.63)g/L>(27.44±1.35)g/L,t=8.978]is higher than the control group(P<0.05),the observation group has no significant difference in creatinine(Scr)level and urea nitrogen(BUN)level compared with the control group(P>0.05).In the observation group,there was no significant difference in the proportion of patients with complete remission,conversion to hemodialysis,and death(P>0.05).The 47 peritoneal dialysis patients,6 received automated peritoneal dialysis,41 cases received routine manual peritoneal dialysis.In patients receiving automatic peritoneal dialysis treatment,the incidence of single peritoneal dialysisrelated peritonitis is higher than that of conventional manual peritoneal dialysis,and the incidence of multiple peritoneal dialysis-related peritonitis is lower than that of conventional manual peritoneal dialysis.Conclusion Peritonitis is a common complication during peritoneal dialysis treatment.Laboratory examination results suggest that there are differences in Hb,Alb and other indicators between patients with single and multiple peritoneal dialysis-related peritonitis,and there is no significant difference in the prognosis of the two.The application of automatic peritoneal dialysis can reduce the occurrence of peritonitis to a certain extent.