盐酸硫必利、安定、苯巴比妥术前给药的临床观察

Clinical Observation of Preoperative Administration of Tiapride Hydrochloride,Valium and Phenobarbital

目的关于盐酸硫必利、安定、苯巴比妥等药物术前用药的临床分析。方法将2019年1月至2021年3月到我院进行手术治疗的120例患者按随机方法分为A组、B组和C组,平均40例。所有患者术前0.50 h均常规肌内注射阿托品0.50 mg,A组术前0.50 h肌内注射盐酸硫必利、B组术前0.50 h肌内注射安定、C组术前0.50 h肌内注射苯巴比妥。对3组的镇静效果、镇痛效果与不良反应的发生率等进行比较。结果A组的镇静效果和镇痛效果明显比B组和C组更好,差异有统计学意义(P<0.05);A组(2例,占5.00%)的不良反应发生率明显比B组(12例,占30.00%)和C组(11例,占27.50%)更低,差异有统计学意义(P<0.05);A组患者的呼吸恢复时间、睁眼时间和拔管时间都明显短于B组与C组,差异有统计学意义(P<0.05);A组术后24 hVAS评分明显比B组和C组低,电子静脉自控式镇痛泵比B组和C组少,电子静脉自控式镇痛泵剩余药量比B组和C组多,差异有显著统计学意义(P<0.05);A组患者术后满意度要明显比B组和C组更高,差异有统计学意义(P<0.05)。结论相对于安定和苯巴比妥,术前通过肌内注射盐酸硫必利能够更好的发挥镇静和镇痛作用,同时能提升用药安全性。

Objective The clinical analysis of preoperative medication of tiapride hydrochloride,diazepam,phenobarbital and other drugs.Methods A total of 120 patients who came to our hospital for surgical treatment from January 2019 to March 2021 were randomly divided into group A,group B and group C,with an average of 40 cases.All patients received routine intramuscular injection of atropine 0.50 mg 0.50 h before operation,group A intramuscular injection of tiapride hydrochloride 0.50 h before operation,group B intramuscular injection of valium 0.50 h before operation,and group C thousands of 0.50 h intramuscular injection of phenobarbital.The sedative effect,analgesic effect and the incidence of adverse reactions of the three groups of patients in this article were compared.Results The sedative and analgesic effects of group A were significantly better than those of group B and group C,and the difference was statistically significant(P<0.05);adverse reactions of group A(2 cases,accounting for 5.00%)the incidence was significantly lower than that of group B(12 cases,accounting for 30.00%)and group C(11 cases,accounting for 27.50%),and the difference was statistically significant(P<0.05).The breathing recovery time of patients in group A,eye-opening time and extubation time were significantly shorter than those of the group B and C group,and the difference was statistically significant(P<0.05).The pain score of group A was significantly lower than that of groups B and group C at 24 hours after operation.Electronic vein self-controlled analgesia there are fewer pumps than group B and group C,and the remaining amount of electronic vein self-control analgesia pump is more than that of group B and C.The difference was statistically significant(P<0.05).The postoperative satisfaction of patients in group A is obvious higher than that of group B and group C,and the difference was statistically significant(P<0.05).Conclusion Compared with diazepam and phenobarbital,preoperative intramuscular injection of tiapride hydrochloride can have a better sedative and analgesic effect,and can improve the safety of medication.It is a recommended preoperative medication.