膳食纤维经肠道微生态途径抑制结肠癌的研究进展

Research Progress on Inhibition of Colon Cancer by Dietary Fiber Via Intestinal Microecological Pathway

目前由于能量摄入过多、膳食纤维摄入过少等问题日益严重以及肥胖病发病率逐年增加,导致结肠癌发病率和死亡率呈逐年增高趋势.深入研究结肠癌的发病机制、寻找科学合理的干预方式是目前医学界亟待解决的问题.近年来,越来越多的研究显示,肠道菌群在结肠癌发生、发展过程中起重要作用,而膳食纤维作为人体必须的七大营养素之一,对于膳食纤维如何调控肠道菌群抑制结肠癌等疾病的具体作用机制仍不确切,未来仍有待于探索.因此本文就膳食纤维、肠道菌群和结肠癌疾病的互作关系进行了综述,可以为临床治疗以及疾病预防提供一定的理论参考.

At present,due to excessive energy intake and lack of dietary fiber,the incidence of obesity is increasing year by year.It is an urgent problem to study the pathogenesis of colon cancer and find scientific and reasonable intervention methods.In recent years,more and more studies have shown that intestinal flora plays an important role in the development of colon cancer.Dietary fiber is one of the seven essential nutrients in human body,and its specific mechanism of regulating intestinal flora and inhibiting colon cancer needs to be further studied.Therefore,this article reviews the interaction between dietary fiber,intestinal flora and colon cancer,in order to provide some theoretical reference for clinical treatment and disease prevention.