环状RNAs与类风湿关节炎骨破坏潜在关系的研究

A potential role of circular RNAs in bone destruction of rheumatoid arthritis

类风湿关节炎(rheumatoid arthritis,RA)骨破坏是一直伴随RA患者病程发展的病理状态,会造成患者关节严重变形,生活质量下降。环状RNAs(circular RNAs,circRNAs)是一类具有环形结构的RNA分子,在多种生物体中广泛存在,并在多种疾病中发挥特殊的生物学功能。大量研究表明circRNAs可以作为miRNA海绵,在治疗RA骨破坏方面具有重要作用。本文就circRNAs在调控细胞凋亡、成骨细胞和破骨细胞分化功能和调控免疫炎症等方面来阐述其与RA骨破坏之间的潜在关系,为研究RA骨破坏的潜在机制和可能的治疗方法提供一种新的途径。

Bone destruction in rheumatoid arthritis(RA)is a pathological state that always accompanies the development of RA,resulting in severe deformation of patients′joints and reducing their life quality.Circular RNAs(circRNAs)are a class of RNA molecules with circular structure,which widely exist in a variety of organisms and play special biological functions in many diseases.A large number of studies proved that circRNAs can act as miRNA sponges and play an important role in the treatment of bone destruction in RA.In this paper,the potential relationship between circRNAs and bone destruction in RA was discussed in terms of the regulation of cell apoptosis,osteoblast and osteoclast differentiation,and the regulation of immune inflammation,so as to provide a new approach for studying the potential mechanism of bone destruction in RA and possible therapeutic methods.