屈螺酮的合成方法综述

Summary of the Synthetic Methods of Drospirenone

屈螺酮是一种高效、低毒、安全性好的新一代孕激素,具有良好的天然孕酮活性。屈螺酮通常与炔雌醇组成复方雌孕激素制剂,临床上被用来作为女性口服避孕药。本文综述了近些年屈螺酮的合成路线并简单展望了其后续的合成工艺改进方向。

Drospirone is a new generation of progesterone with high efficiency,low toxicity and good safety,which owned excellent natural progesterone activity.Drospirone is usually combined with ethinylestradiol to form a compound estrogen and progesterone preparation,which is clinically used as an oral contraceptive for women.This paper reviews the synthetic routes of drospirone in recent years,and briefly looks forward to the improvement direction of its subsequent synthetic process.