二甲双胍治疗血液肿瘤的研究进展

Progress of metformin for treatment of blood cancers

二甲双胍是治疗2型糖尿病的一线药物。目前越来越多的证据表明,二甲双胍可以降低糖尿病或非糖尿病患者的癌症发病率和癌症相关的病死率。而且研究表明二甲双胍还可作为白血病、淋巴瘤和多发性骨髓瘤患者的治疗药物。在此篇文章中,我们回顾了目前关于二甲双胍在血液肿瘤中的应用现状和其可能的抗癌机制。

Metformin is a first line drug of therapy for type 2 diabetes mellitus.Recently more and more evidence indicates that metformin use has been found to be connected with a reduced incidence of cancer and cancer-related mortality in patients with or without diabetes.Moreover,studies indicate that metformin can also be used as a therapeutic agent in patients with leukemia,lymphomas and multiple myeloma.In this article,we review current treatments on the anticancer activities of metformin and the underlying mechanisms in blood cancers.