摘要
外泌体能穿透血脑屏障,在外周循环中高度稳定并很好地保护疾病相关分子,所以可以用来监测疾病的发展,优化早期诊断和治疗。利用外泌体作为PD等中枢神经系统疾病的生物标志物前景广阔.本文现围绕外泌体在P D中的病理生理作用以及作为P D生物标志物的研究进展综述如下。
Exosomes can penetrate the blood-brain barrier and are highly stable in the peripheral circulation,which can protect disease-related molecules,so they can be used to monitor the development of disease and optimize early diagnosis and treatment.Therefore,the use of exosomes as biomarkers of central nervous system diseases is very promising.This article reviews the pathophysiological role of exosomes in Parkinson's disease and the research progress of exosomes as biomarkers of Parkinson's disease.
作者
周丽娜
王洪新
Zhou Lina;Wang Hongxin(Department of Neurology,Fourth Center Hospital of Tianjin,Tianjin 300140,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2021年第12期1270-1274,共5页
Chinese Journal of Neuromedicine
基金
天津市卫生健康科技项目(ZC20110)
