脂肪酸结合蛋白7在中枢神经系统中的研究进展

Recent advance in fatty acid binding protein 7 in central nervous system

脂肪酸结合蛋白7(FABP7)是一种小分子胞浆蛋白,作为细胞内脂肪酸伴侣与DHA等配体特异性结合并广泛参与机体的生理病理过程。在脑发育过程中,FABP7在神经干细胞、星型胶质细胞和少突胶质前体细胞中大量表达,在调控中枢神经系统疾病病理过程中发挥重要作用。本文现围绕FABP7的结构、功能、表达及其在中枢神经系统疾病中的相关研究进展综述如下。

Fatty acid binding protein 7(FABP7)is a small molecular cytoplasmic protein.As a cellular fatty acid chaperone,it binds specifically to ligands such as DHA and is widely involved in physiological and pathological processes.During brain development,FABP7 is heavily expressed in neural stem cells,astrocytes and oligodendrocyte precursor cells,which plays a key role in regulating the pathology process of the central nervous system diseases.This article reviews the structure,expression and function of FABP7 and its related research progress in central nervous system disease.