肌腱干/祖细胞的研究进展

Research into tendon stem/progenitor cells

严重肌腱损伤会对普通患者的活动能力和生活质量产生重大影响,同时对职业运动员的职业生涯造成重大打击。目前,手术治疗肌腱损伤并不能获得令人满意的效果。对临床医生而言,肌腱损伤仍具有挑战性。肌腱干/祖细胞(TSPCs)的发现以及对其不断深入研究,为肌腱的修复和再生提供了新的方向,推动了肌腱组织工程的不断发展。本文对TSPCs的特性、老化、分离培养及其在肌腱修复的相关应用进展进行系统归纳整理,并对TSPCs的研究方向进行分析和展望。

Severe tendon injury will impair the mobility and quality of life of ordinary patients and come as a major blow to the career of professional athletes.As the current surgical treatment of tendon injury cannot achieve satisfactory results,the injury is still challenging for clinicians.The discovery of tendon stem/progenitor cells(TSPCs)and the continuous in-depth study of them provide a new direction for tendon repair and regeneration,and promote the continuous development of tendon tissue engineering.This article systematically summarizes the characteristics,aging,isolation and culture of TSPCs in tendon repair,and progress in their related applications as well.The research direction of TSPCs is also analyzed and prospected.