2011-2020年金昌队列人群恶性肿瘤死亡趋势及疾病负担分析

Study on cancer death trend and disease burden in Jinchang Cohort,2011—2020

目的掌握金昌队列人群恶性肿瘤的死亡趋势及其造成的疾病负担,确定肿瘤防治的高危人群和核心病种,为肿瘤防治和健康干预提供基础数据。方法随访队列人群近10 a的恶性肿瘤死因,利用职工唯一识别码构建用于分析恶性肿瘤死亡率和疾病负担的数据库,分析恶性肿瘤死亡率、潜在减寿年数(PYLL)和潜在工作损失年数(WYPLL)近10 a的变化趋势。结果 2011—2020年,金昌队列人群恶性肿瘤粗死亡率为252.19/10万,标化死亡率为131.18/10万,其变化趋势差异均无统计学意义(P> 0.05);恶性肿瘤造成的男性PYLL (4 272.40人年)是女性(2 147.64人年)的1.99倍,女性平均潜在减寿年数(AYLL)(14.91 a)是男性(9.52 a)的1.57倍;恶性肿瘤导致的男性WYPLL (2 485.00人年)是女性(1 035.00人年)的2.40倍,女性平均潜在工作损失年数(AWYPLL)(10.78 a)是男性(10.02 a)的1.08倍,男、女性恶性肿瘤造成的疾病负担近10 a变化趋势差异均无统计学意义;总人群中首位恶性肿瘤PYLL和WYPLL是肺癌,其次是肝癌、胃癌、食管癌和结直肠癌,男性恶性肿瘤AYLL和AWYPLL首位均是肝癌,女性恶性肿瘤AYLL和AWPYLL首位分别是食管癌和胃癌。结论金昌队列人群近10 a恶性肿瘤死亡率和疾病负担呈相对稳定状态,疾病负担较重的恶性肿瘤前5位分别为肺癌、肝癌、胃癌、食管癌和结直肠癌。

Objective To understand the death trend of cancer in the Jinchang Cohort and the burden of disease caused by malignant tumors, identify high-risk individuals and core diseases for cancer prevention and provide basic data for cancer prevention and health intervention. Methods By following up the cause of cancer death in this population for the past ten years, the unique identification code of employees was used to construct a database for analyzing the mortality and disease burden of malignant tumors, the trends of malignant tumor mortality, potential years of life lost(PYLL) and work years of potential life lost(WYPLL).Results From 2011 to 2020, the crude cancer mortality rate in the Jinchang Cohort was 252.19/100 000, and age-standardized mortality rate was 131.18/100 000. PYLL caused by malignant tumors in men(4 272.40 person-years) was 1.99 times that of women(2 147.64 person-years), average potential years of life lost(AYLL)in women(14.91 years) were 1.57 times those of men(9.52 years);WPYLL caused by cancers in males(2 485.00 person-years) was 2.40 times that of females(1 035.00 person-years), and work years of potential life lost(AWPYLL) in females(10.78 years) were 1.08 times those of males(10.02 years). There was no significant difference in the trend of changes in the burden of disease between men and women(P > 0.05). The top cancer causing PYLL and WYPLL in the total population was lung cancer, followed by liver cancer, stomach cancer, esophageal cancer and colorectal cancer;the first cancer that caused AYLL and AWYPLL in men was liver cancer, with top cancers causing AYLL and AWPYLL being esophageal cancer and gastric cancer respectively among women. Conclusion The cancer mortality and disease burden in the Jinchang cohort had been relatively stable in the past ten years. The top five malignant tumors that caused a heavier disease burden were in order, lung, liver, gastric, esophageal and colorectal cancer.