2015年至2020年我院1026例地高辛血药浓度监测结果分析

Serum Concentration Monitoring of Digoxin:An Analysis of 1026 Cases During 2015-2020

目的:分析地高辛血药浓度监测结果及其影响因素,为临床合理用药提供参考。方法:基于回顾性调查法对赣南医学院第一附属医院2015年至2020年进行地高辛血药浓度监测的1026名住院患者的年龄、性别、体质量、电解质、肾功能、合并去乙酰毛花苷、TDM值等进行统计和分析。结果:1026次监测结果显示,地高辛血药浓度(1.87±1.81)ng/mL;血药浓度在有效治疗范围0.5~1.75 ng/mL 480例(46.78%);体质量、年龄、肾功能、合并去乙酰毛花苷注射液等对地高辛血药浓度有显著性影响;男女性患者血药浓度差异无统计学意义(P>0.05);"0.125 mg,1次/d"给药剂量安全性较其他给药方案好;高血钾组与正常组、低血钾组的地高辛血药浓度差异无统计学意义(P>0.05)。结论:地高辛的血药浓度主要受年龄、肾功能、给药剂量及合并去乙酰毛花苷注射液影响。临床应结合地高辛血药浓度结果与患者实际临床表现,制定合理个体化给药方案。

Objective:To analyze the monitoring results of serum concentrations of digoxin,to provide reference for clinical rational drug use.Methods:Based on the retros pective investigation method,1026 patients underwent blood concentration monitoring of digoxin were selected from First Affiliated Hospital of Gannan Medical University during 2015-2020.The age,gender,weight,electrolyte,renal function,additional intravenous digoxin administration and TDM value of 1026 inpatients were statistically and analyzed.Results:Results of 1026 times monitoring showed that the average blood concentration of digoxin was(1.87±1.81)ng/mL;blood concentration of 480 cases were in normal range(0.5-1.75)ng/mL,accounting for 46.78%;body weight,age,renal function,and deacetyl injection had significant effects on the blood concentration of digoxin;there was no significant difference in blood concentration of digoxin between male and female patients(P>0.05);the dose safety of"0.125 mg,qd"was better than other administration schemes;the mean blood concentration of digoxin in the high potassium group,the normal group and the low potassium group(P>0.05).Conclusion:The blood concentration of digoxin was mainly affected by age,renal function,dosage and additional intravenous digoxin administration.Individual therapy regimens should be formulated according to blood concentration monitoring and clinical symptom of patients.