盐酸舍曲林片联合重复经颅磁刺激治疗老年期抑郁症的临床研究

Clinical Study of Sertraline Hydrochloride Tablets Combined with Repeated Transcranial Magnetic Stimulation in the Treatment of Senile Depression

目的研究对老年抑郁症患者给予重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)联合盐酸舍曲林治疗的效果。方法方便选取2020年3月—2021年3月该院收治的56例老年抑郁症患者为研究对象,随机分为两组,即对照组(n=28,伪rTMS+盐酸舍曲林)、观察组(n=28,rTMS+盐酸舍曲林),对比两组治疗效果。结果对照组治疗1周MMSE(22.50±3.14)分,治疗2周MMSE(20.67±2.74)分,治疗4周MMSE(19.02±2.56)分;观察组治疗1周MMSE(20.86±2.10)分,治疗2周MMSE(16.58±2.41)分,治疗4周MMSE(13.98±2.33)分,两组对比差异有统计学意义(t=2.297、5.931、7.704,P<0.05)。对照组治疗1周HAMD(25.01±2.53)分,治疗2周HAMD(19.25±2.37)分,治疗4周HAMD(15.36±2.45)分;观察组治疗1周HAMD(21.39±3.21)分,治疗2周HAMD(17.07±2.87)分,治疗4周HAMD(10.96±1.73)分,两组对比差异有统计学意义(t=4.687、3.099、7.763,P<0.05)。两组不良反应对比,差异无统计学意义(P>0.05)。治疗前,两组GQOLI-74评分对比差异无统计学意义(P>0.05);治疗后,观察组GQOLI-74评分高于对照组,差异有统计学意义(P<0.05)。结论对老年期抑郁症患者给予盐酸舍曲林片联合rTMS治疗,能够有效改善患者的认知功能,改善抑郁症状,不易增加不良反应,同时对于患者生活质量有积极作用。

Objective To study the effect of repetitive transcranial magnetic stimulation(rTMS)combined with sertraline hydrochloride in the treatment of senile depression.Methods The 56 elderly patients with depression admitted to the hospital from March 2020 to March 2021 were conveniently selected as the research objects.They were randomly divided into two groups,namely the control group(n=28,pseudo-rTMS+sertraline hydrochloride)and the observation group(n=28,rTMS+sertraline hydrochloride),and the treatment effects of the two groups were compared.Results The control group was treated for 1 week with MMSE(22.50±3.14)points,2 weeks with MMSE(20.67±2.74)points,and 4 weeks with MMSE(19.02±2.56)points,the observation group was treated for 1 week with MMSE(20.86±2.10)points,2 weeks with MMSE(16.58±2.41)points,and 4 weeks with MMSE(13.98±2.33)points,the difference between the two groups was statistically significant(t=2.297,5.931,7.704,P<0.05).The control group had HAMD(25.01±2.53)points for 1 week of treatment,HAMD(19.25±2.37)points for 2 weeks of treatment,and HAMD(15.36±2.45)points for 4 weeks of treatment,the observation group had HAMD(21.39±3.21)points for 1 week of treatment,HAMD(17.07±2.87)points for 2 weeks of treatment,and HAMD(10.96±1.73)points for 4 weeks of treatment,the difference between the two groups was statistically significant(t=4.687,3.099,7.763,P<0.05).There was no statistically significant difference between the two groups of adverse reactions(P>0.05).Before treatment,there was no statistically significant difference in GQOLI-74 score between the two groups(P>0.05).After treatment,the GQOLI-74 score of the observation group was higher than the control group,the difference was statistically significant(P<0.05).Conclusion Sertraline hydrochloride tablets combined with rTMS treatment for elderly depression patients can effectively improve the cognitive function of the patients,improve the symptoms of depression,and it is not easy to increase the adverse reactions.At the same time,it has a positive effect on the quality of life of the patients.