阿司匹林联合复合维生素对妊娠高血压子痫前期的预防效果

The Preventive Effect of Aspirin Combined with Multivitamins on Pregnancy-induced Hypertension and Preeclampsia

目的探讨阿司匹林、复合维生素联合预防妊娠高血压子痫前期的效果及安全性。方法方便选择2019年2月—2021年2月该院收诊治疗妊娠期高血压患者90例观察分析,以随机抽签方式分为两组,观察组患者采用阿司匹林、复合维生素联合预防治疗,对照组患者服用安慰剂,观察统计两组患者预防效果,记录患者不同时间并发子痫前期概率,监测各组患者预防治疗期间血压水平变化,观察并统计各组新生儿不良情况发生概率。结果观察组患者预防总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组患者用药后不同时间并发子痫前期概率均明显低于对照组,差异有统计学意义(P<0.05);两组患者入院时血压水平差异无统计学意义(P>0.05),治疗后观察组患者收缩压(115.96±3.02)mmHg、舒张压(80.92±1.03)mmHg均低于对照组,差异有统计学意义(t=13.846、31.792,P<0.05);观察组新生儿出现宫内窘迫等不良情况发生率低于对照组,差异有统计学意义(P<0.05)。结论妊娠高血压患者经阿司匹林、复合维生素联合用药能够有效预防发生子痫前期情况,改善新生儿及分娩结局,安全性佳。

Objective To explore the effect and safety of aspirin and multivitamins in preventing pregnancy-induced hypertension and preeclampsia.Methods Observation and analysis of 90 patients with hypertension during pregnancy were conveniently selected in the hospital From February 2019 to February 2021,and they were divided into two groups by random drawing.Patients in the observation group were treated with aspirin and multivitamins for preventive treatment,and patients in the control group were treated with placebo,and the preventive effects of the two groups were observed and counted.Record the probability of patients with preeclampsia at different times,monitor the changes in blood pressure levels during preventive treatment of patients in each group,observe and count the probability of adverse neonatal conditions in each group.Results The total effective rate of prevention in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05);the probability of preeclampsia in the observation group at different times after medication was significantly lower than that in the control group,the difference was statistically significant(P<0.05);there was no statistically significant difference in blood pressure levels between the two groups at admission(P>0.05).After treatment,the systolic blood pressure(115.96±3.02)mmHg and diastolic blood pressure(80.92±1.03)mmHg of the observation group were lower than those of the control group,the difference was statistically significant(t=13.846,31.792,P<0.05);the incidence of adverse conditions such as intrauterine distress among newborns in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of aspirin and multivitamins for patients with pregnancy-induced hypertension can effectively prevent preeclampsia,improve neonatal and childbirth outcomes,and has good safety.