血管生成拟态与结直肠癌不良预后相关性的meta分析

Meta-analysis of the relationship between vasculogenic mimicry and poor prognosis in patients with colorectal cancer

目的探讨血管生成拟态(VM)与结直肠癌患者不良预后的相关性。方法计算机检索建库至2021年4月PubMed、Embase、Cochrane Library、Web of Science、CBM、CNKI、VIP及万方数据库发表的关于VM与结直肠癌不良预后关系的队列研究,采用Stata 14.0软件进行meta分析,计算合并风险及95%CI以评估VM阳性对结直肠癌不良预后的价值,并进行亚组分析。结果最终纳入5篇文献进行meta分析,共769例患者,VM阳性患者203例。meta分析结果显示,VM阳性与不良预后之间存在显著相关性(HR=2.433,95%CI:1.844~3.023,P<0.001)。亚组分析显示样本量、患者预后情况的提取方法、组间可比性校正对VM阳性与患者预后相关性无明显影响(I2<50%,P>0.1)。结论VM阳性与结直肠癌不良预后有显著相关性,VM可能为临床治疗结直肠癌提供了潜在方向。

Objective To investigate the relationship between vasculogenic mimicry(VM)and poor prognosis in patients with colorectal cancer.Methods The cohort studies on the relationship between VM and poor prognosis of colorectal cancer published in PubMed,Embase,Cochrane Library,Web of Science,CBM,CNKI,VIP,and Wanfang Data from inception to April 2021 were selected by computer.Then meta-analysis was performed by Stata 14.0 software.The pooled hazard ratio and its 95%CI were calculated.The subgroup analysis was performed.Results Five studies were included,including 769 patients and 203 VM positive patients.Meta-analysis showed a significant correlation between positive VM and poor prognosis(HR=2.433,95%CI:1.844-3.023,P<0.001).Subgroup analysis showed that sample size,extraction method of patients’prognosis,and comparability adjustment between groups had no significant influence on the correlation between VM positivity and patients’prognosis(I2<50%,P>0.1).Conclusion VM positive is significantly correlated with poor prognosis of colorectal cancer,and VM can be a potential direction for clinical treatment of colorectal cancer.