半夏泻心汤配合针刺治疗寒热错杂型慢性萎缩性胃炎的效果

Effect of Banxia Xiexin Decoction combined with acupuncture in the treatment of chronic atrophic gastritis with syndrome of cold and heat complex

目的探讨半夏泻心汤配合针刺治疗寒热错杂型慢性萎缩性胃炎(CAG)的效果。方法选择2020年7月至2021年3月江苏省苏州市中西医结合医院和苏州市中医医院收治的78例寒热错杂型CAG患者作为研究对象,按照随机数字表法将其分为对照组(39例)和观察组(39例)。对照组采用常规西药联合针刺治疗,观察组在对照组的基础上采用半夏泻心汤治疗,两组均治疗4周。观察两组临床疗效、胃蛋白酶原Ⅰ(PGⅠ)/胃蛋白酶原Ⅱ(PGⅡ)、白细胞介素-17(IL-17)、中医证候评分以及安全性的差异。结果治疗后,观察组总有效率高于对照组(P<0.05);两组PGⅠ/PGⅡ均较治疗前升高,且观察组高于对照组(P<0.05);两组血清IL-17水平均较治疗前降低,且观察组低于对照组(P<0.05);两组中医证候评分均较治疗前降低,且观察组低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论半夏泻心汤配合针刺治疗寒热错杂型CAG患者效果确切,可减轻机体炎症反应,调节PGⅠ/PGⅡ平衡,安全可靠。

Objective To explore the effect of Banxia Xiexin Decoction combined with acupuncture in the treatment of chronic atrophic gastritis(CAG)with syndrome of cold and heat complex.Methods A total of 78 CAG patients with syndrome of cold and heat complex admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Suzhou Hospital of Traditional Chinese Medicine,Jiangsu Province from July 2020 to March 2021 were selected as the research subjects.According to random number table method,they were divided into control group(39 cases)and observation group(39 cases).The control group was treated with conventional Western medicine combined with acupuncture,and the observation group was treated with Banxia Xiexin Decoction on the basis of the control group,and both groups were treated for four weeks.The clinical efficacy,pepsinogenⅠ(PGⅠ)/pepsinogenⅡ(PGⅡ),interleukin-17(IL-17),traditional Chinese medicine syndrome score and safety were observed between the two groups.Results After treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).The PGⅠ/PGⅡin the two groups was higher than that before treatment,which in the observation group was higher than that in the control group(P<0.05).The serum IL-17 levels in the two groups were lower than that before treatment,which in the observation group was lower than that in the control group(P<0.05).The traditional Chinese medicine syndrome symptom scores in the two groups were lower than that before treatment,which in the observation group was lower than that in the control group(P<0.05),there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Banxia Xiexin Decoction combined with acupuncture in the treatment of CAG patients with syndrome of cold and heat complex have a definite effect,which can reduce the body’s inflammation,and regulate PGⅠ/PGⅡbalance,safe,and reliable.