规模化种猪场口蹄疫病免疫净化及效果评估

Immune purification and effect evaluation of foot and mouth disease in large-scale breeding farms

为推动口蹄疫病的净化工作,本研究通过集成疫苗免疫、免疫程序调整、检测、监测、淘汰及生物安全等技术,通过5年的严格实施,在湖北和安徽某种猪场成功净化了猪口蹄疫病,建立了阴性猪群。对采集的血液、扁桃体、唾液和环境样品进行了血清学/病原学检测,结果显示安徽某种猪场3ABC抗体阳性率由7.9%降至0.0%,O型抗体阳性率从81.3%提升到94.3%;湖北某种猪场3ABC抗体阳性率始终维持在0.0%,O型抗体阳性率从89.7%提升到93.0%,病原学检测均为阴性。上述结果表明,本研究采取的规模化种猪场口蹄疫免疫净化措施效果显著,具有推广应用价值。

In order to clean the foot-and-mouth disease(FMD)in some large-scale breeding farms in Hubei and Anhui Provinces,the comprehensive measures via the integration of vaccine immunization,detection,monitoring,elimination and biosafety technologies were taken in this study.After five years of efforts,the disease was successful cleaned and the FMD-negative pig populations were established.Serological/etiological assays were also performed for the samples of blood,tonsil,saliva,and environmental swabs to validate the efficacy.The results showed that serological 3 ABC antibody positive rate of the farms in Anhui Province decreased from 7.9%to 0.0%,while the rate of positive O antibody increased from 81.3%to 94.3%;3 ABC antibody positive rate of the farms in Hubei Province maintained at 0.0%,average positive rate of O antibody increased from 89.7%to 93.0%.The above results demonstrated that the measures taken in this study are effective in controlling and eliminating FMD.