6例乳腺乳头腺瘤临床病理分析

Clinicopathological changes of nipple adenoma of six cases

目的探讨乳腺乳头腺瘤患者的临床病理学特点及分子遗传学特征。方法回顾性分析6例乳腺乳头腺瘤患者的临床资料。结果6例患者肿瘤均位于乳头部及乳晕区,组织学形态复杂多样,增生导管上皮可呈腺管状、乳头状、筛状及实性的生长排列方式。以腺病型和上皮增生型为主3例,以腺病型和假浸润型为主1例,以上皮增生型和假浸润型为主1例,以上皮增生型为主1例。6例导管腔内均未见明显坏死。腺管及假浸润灶周围肌上皮标记P63、calponin和CD10表达阳性6例,增生上皮CK5/6表达阳性6例。PIK3CA基因H1047R突变2例。结论乳腺乳头腺瘤病理形态复杂多样,可出现PIK3CA基因突变。

Objective To explore the clinicopathological features and molecular genetic features of nipple adenoma.Methods The clinical data of six cases of nipple adenoma were retrospectively analyzed.Results All these tumors were located in the nipple and areola region,with complex and varied histological morphology.The proliferated ductal epithelium was tubular,papillary,cribriform and solid.The clincopathological type was mainly adenosis type and epithelial hyperplasia type in three cases,adenosis type and pseudo-infiltration type in one case,epithelial hyperplasia type and pseudo-infiltration type in one case,and epithelial hyperplasia type in one case.No obvious intraductal necrosis was found in six cases.P63,calponin and CD10 were positive in the myoepithelial cells around the glandular duct and pseudo-infiltrative area in six cases,and CK5/6 was positive in the proliferated epithelial cells in six cases.PIK3 CA gene H1047 R mutation was found in two cases.Conclusion Nipple adenoma has complex and diverse pathological morphology,and the mutation of PIK3 CA gene may occur.