氧化三甲胺与神经系统疾病相关性研究进展

Relationship between trimethylamine-N-oxide and nervous system diseases

肠道菌群的构成及其代谢产物影响人类疾病的发生、发展。氧化三甲胺可通过降低突触蛋白表达、诱导氧化应激、促进神经炎症、破坏血脑屏障及促进动脉粥样硬化等途径对神经系统产生损害,也可作为渗透保护剂促进蛋白折叠、稳定蛋白结构发挥其有利影响。氧化三甲胺与阿尔兹海默病、帕金森病、肌萎缩侧索硬化症、缺血性脑卒中有一定相关性。本文就氧化三甲胺与神经系统疾病相关性的研究进展作一综述。

The composition and metabolism of intestinal flora affect the occurrence and development of human diseases.Trimethylamine oxide(TMAO)damages the nervous system by reducing synaptic protein expression,inducing oxidative stress and neuroinflammation,destroying the blood-brain barrier,and promoting atherosclerosis.But it is also used as an osmo-protective agent to exert its beneficial effects by promoting protein folding and stabilizing protein structure.TMAO is correlated with Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and ischemic stroke.This paper reviews the research progress on the correlation between TMAO and nervous system diseases.