男性结直肠癌超额发病风险中已知危险因素的解释效果分析

Explanatory Effects of Known Risk Factors in Excess Incidence Risk of Colorectal Cancer in Men

[目的]结直肠癌发病性别差异较大,但原因不明,该研究拟评价男性结直肠癌发病超额风险中已知危险因素的解释比例。[方法]针对我国4个省参加结直肠癌筛查项目的参与者,开展结直肠癌危险因素分析。采用Logistic回归和超额风险解释度分析(explained share of excess risk,ERR)评价男性超额风险的危险因素解释比例。[结果]男性结直肠癌发病风险是女性的1.8倍(OR=1.80,95%CI:1.62~1.99,P<0.01);该部分超额风险可以被烟草暴露、酒精摄入、蔬菜摄入、水果摄入、畜肉摄入、粗粮摄入、体育锻炼、家族史等因素解释31.3%。[结论]男性结直肠癌超额发病风险仅有部分可被已知危险因素解释,进一步探索包括遗传易感性等在内更多的结直肠癌危险因素,对于结直肠癌一、二级预防意义重大。

[Purpose]To explore what extent is male excess incidence risk of colorectal cancer(CRC)explained by known risk factors.[Methods]Risk factors for CRC were evaluated among community residents from four provinces in China who participated in China Colorectal Cancer Screening Program.Logistic regression and explained share of excess risk(EER)analysis were used.[Results]Males had 1.8-fold increase risk in CRC compared with females(OR=1.80,95%CI:1.62~1.99,P<0.01).31.3%of the excess risk could be explained by risk factors such as behavior and diet.[Conclusion]Part of the male excess risk of CRC could be explained by risk factors.Further CRC risk factor detection,including genetics,need to be further investigated which is critical for CRC primary and secondary prevention.