抑郁症认知功能障碍神经生物学机制研究进展

Advances in neurobiological mechanisms of cognitive dysfunction in depression

认知功能障碍是许多精神障碍的症状性领域,抑郁症患者的认知缺陷是导致职业和功能残疾的重要原因,多种相互作用的神经生物学机制(如神经炎症)与抑郁症的认知缺陷有关。现归纳与抑郁症认知功能相关的多种生物学机制,包括神经回路损伤、神经递质系统、神经内分泌系统、炎症反应、神经营养因子等,分析抑郁症合并认知功能障碍患者生物学机制的研究进展。目前,国内外尚缺乏对抑郁症认知功能障碍的深入探索,将神经系统、内分泌系统和免疫系统整合起来,更深层次地探索抑郁症认知功能障碍的生物学机制是未来的方向。

Cognitive impairment is a symptomatic area of many mental disorders.Cognitive impairment in patients with depression is an important cause of occupational and functional disability.Multiple interacting neurobiological mechanisms(such as neuroinflammation)are related to cognitive deficits in depression.This paper summarizes a variety of biological mechanisms related to cognitive function of depression,including brain mechanism,neurotransmitter system,neuroendocrine system,inflammatory response and neurotrophic factors,and analyzes the research progress of biological mechanism of patients with depression complicated with cognitive impairment.At present,there is still a lack of in-depth exploration of cognitive impairment of depression in China and abroad.The future direction is to integrate the nervous system,endocrine system and immune system and further explore the biological mechanism of cognitive impairment of depression.