tRNA来源的非编码小RNA在消化系统肿瘤中的研究进展

Advance in Study on tRNA-derived Small Non-coding RNAs in Gastrointestinal Tumors

转移核糖核酸(tRNA)来源的非编码小RNA(tsRNAs)由成熟或前体tRNA在不同位点特异性剪切生成,广泛存在于原核生物和真核生物转录组,是一类新的基因表达调控分子,具有多种生物学功能。tsRNAs参与应激反应、蛋白质翻译、核糖体生物合成以及调节免疫反应等生理和病理过程,其表达失调与人类多种疾病的发生、发展关系密切。本文就tsRNAs在消化系统肿瘤中的研究进展作一综述。

Transfer RNA( tRNA)-derived small non-coding RNAs( tsRNAs) are generated through specific endonucleolytic cleavage of mature or precursor tRNA at different sites and exist widely in prokaryotic and eukaryotic transcriptome,and are a new class of gene expression regulators with a variety of biological functions. tsRNAs participate in some physiological and pathological processes,including stress response,protein translation,ribosomal biosynthesis and regulating immunity. Dysregulation of tsRNAs is closely related with the occurrence and development of many human diseases. This article reviewed the advance in study on tsRNAs in gastrointestinal tumors.